The human immune system is composed of a distributed network of cells circulating throughout the body, which must dynamically form physical associations and communicate using interactions between their cell-surface proteomes1. Despite their therapeutic potential2, our map of these surface interactions rem...
Top Anatomy Diagrams Diagram - Top Anatomy Diagrams Chart - Human anatomy diagrams and charts explained. This anatomy system diagram depictsTop Anatomy Diagramswith parts and labels. Best diagram to help learn about health, human body and medicine. ...
(A) This diagram illustrates the approach to analyzing the immunophenotyping data obtained by flow cytometry. It is not meant to convey differentiation stages of leukocyte populations, though that property is largely reflected in this diagram. Each “lineage” of a subset of leukocytes was identified...
The immune system can identify and eliminate cancer cells through both innate and adaptive mechanisms; however, such antitumor responses can be inhibited by the microenvironment through a process known as immunosuppression. Cancer immunotherapy aims to manipulate both immunosuppressive and immunostimulatory mec...
Human thymic epithelial tumors (TET) are common malignancies in the anterior mediastinum with limited biological understanding. Here we show, by single cell analysis of the immune landscape, that the developmental pattern of intra-tumoral T-cells identif
HIV is an RNA retrovirus that causes acquired immunodeficiency syndrome (AIDS) by attacking the cells of the immune system (helper [CD4] lymphocytes and monocytes). Infection of these cells leads to an eventual breakdown of the immune system, making the patient susceptible to opportunistic infections...
A Protocol diagram of the time courses of the Ri. transplantation and behavioral tests. The mice were exposed to CRS and then the behavioral tests were conducted. Half of the CTR and CRS mice were selected for Ri. gavaging, while the other mice were administered equal volumes of sterile ...
To this aim, we generated a humanized CD147 knock-in (hCD147KI) mouse model in the immunocompromised NOD-scid IL2Rgammanull (NSG) background, which lacks a functional immune system (characterized by a lack of functional T, B, and Natural Killer cells). We performed several assays to dete...
c, Venn diagram showing overlap between WNT4-induced increases in chromatin accessibility in GFP+ cells and increases in HILO gene expression (upper panel), and gene ontology pathways enriched in the intersection gene set. d, Motifs enriched in the intersection gene set from c. e, Chromatin ...
“Methods”). The cortical regions were enriched for thymic T cell selection, thymocyte apoptotic process and T cell receptor signaling pathway, while medulla regions were involved in processes such as negative regulation of immune system process, leukocyte migration and regulation of cell-cell ...