The immune system is distinctive for being a distributed system. It is not fixed to a single localized organ in the body, but rather is made up of numerous specialized cell types that must adaptably organize their intercellular connections to respond to pathogens and other threats wherever they ...
The immune system can identify and eliminate cancer cells through both innate and adaptive mechanisms; however, such antitumor responses can be inhibited by the microenvironment through a process known as immunosuppression. Cancer immunotherapy aims to manipulate both immunosuppressive and immunostimulatory mec...
(A) This diagram illustrates the approach to analyzing the immunophenotyping data obtained by flow cytometry. It is not meant to convey differentiation stages of leukocyte populations, though that property is largely reflected in this diagram. Each “lineage” of a subset of leukocytes was identified...
c, Venn diagram showing overlap between WNT4-induced increases in chromatin accessibility in GFP+ cells and increases in HILO gene expression (upper panel), and gene ontology pathways enriched in the intersection gene set. d, Motifs enriched in the intersection gene set from c. e, Chromatin ...
The humanimmune systemcan react to monoclonal antibodies as foreign antigens by producing its own antibodies to different epitopes on the molecule. It can produce anti-idiotypic, antiallotypic, or antimouse antibodies to the Fv region, the Fc region, or murine epitopes, respectively. Antibodies ...
Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes
Sankey diagram showing the topics, pathogen types and approaches applied in the research presented Full size image Key findings Spatio-temporal surveillance on disease transmission patterns Two articles address the spatial distribution of risk factors, in the context of surveillance Xue et al. [20] de...
To this aim, we generated a humanized CD147 knock-in (hCD147KI) mouse model in the immunocompromised NOD-scid IL2Rgammanull (NSG) background, which lacks a functional immune system (characterized by a lack of functional T, B, and Natural Killer cells). We performed several assays to dete...
E Network diagram displaying predicted TFs-novel target gene pairs, as determined by integration of ATAC-Seq footprinting and inferred TF activity-gene expression correlation. For the box plot in B, box limits extend from the 25th to 75th percentile, while the middle line represents the median. ...
Immune cell–vasculature interactions in the prenatal brain To characterize the interaction between microglia and blood vessels in the prenatal human brain, we used light-sheet microscopic imaging on optically cleared coronal sections from the germinal matrix and frontal CTX at GW20 and GW35 (Extended...