The human immune system is composed of a distributed network of cells circulating throughout the body, which must dynamically form physical associations and communicate using interactions between their cell-surface proteomes1. Despite their therapeutic potential2, our map of these surface interactions rem...
当敌军(病菌)要入侵我们时,军队(免疫力)就会站出来识别、定位和消灭敌军。 Let's focus on immunity first, which is the ability of the immune system to fight against pathogens. If immunity is like an army, while the virus ...
Immune system - Interferons, Antibodies, Cells: Another group of proteins that provide protection are the interferons, which inhibit the replication of many—but not all—viruses. Cells that have been infected with a virus produce interferon, which sends
In central nervous system (CNS), TYROBP mainly expressed in microglia and oligodendrocytes and is an important regulator of microglia activity30,31. Furthermore, immune infiltration analysis was performed using the CIBERSORT method and TYROBP expression was verified in different tissues from ICH by ...
APCs present antigens to T cells and transform them to effector T cells, which is strengthened by CD4+T cells. Cytokines released from natural killer T (NKT) cells and M1 macrophages protect against cancer cells. However, when cancer cells escape the immune system, effector T cells are render...
Meanwhile, external factors, such as a reprogrammed immunosuppressive tumor microenvironment (TME), also play important roles in escaping the surveillance of the host immune system and promoting tumor progression. Firing up the immunosuppressive TME might improve the tumor immunogenicity, T cell ...
Immune thrombocytopenia (ITP) is a rare, acquired autoimmune disorder resulting from the destruction of platelets in the reticuloendothelial system due to anti-platelet antibodies and other immune processes [1, 2]. The cause of this platelet-specific autoimmunity is complex and poorly understood, but...
The development of single-cell detection platforms has enabled deep profiling of the heterogeneity of tumors and the immune system both within individual tumors and between patients [9, 10]. Genomic single-cell sequencing methods, which detect mutations at the DNA level, have been used to confirmed...
Understanding the architecture of the immune system of WBPH is critical to study the molecular mechanisms of viral transmission by insect vectors. In this study, genome-wide identification of WBPH immune genes was performed based on the assembled WBPH genome and transcriptome data. In total, 348...
The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we elucidate the impact of evolutionary and immune-related forces on editi