The human immune system is composed of a distributed network of cells circulating throughout the body, which must dynamically form physical associations and communicate using interactions between their cell-surface proteomes1. Despite their therapeutic potential2, our map of these surface interactions rem...
Mucosal immunityis considered the localimmune system, and the term implies regional limitation[1]. Themucosal immune systemis a complex network composed of innate cells, acquiredimmune cellsand their derivatives, which work together to protect its integrity through the cooperation of singlecell epitheliu...
a Genetic correlation matrix of nine immune-mediated diseases estimated with LD score regression. Shades of blue and red indicate positive and negative correlations respectively. Blue represents Fgut, green Faid and red Falrg. b Path diagram of the three-factor model of immune-mediated diseases. ...
These are small solid structures located at different points along the lymphatic system. Their function is to trap the microorganisms or other antigens, that enter the lymph and tissue fluid. Therefore, the antigens trapped in the lymph nodes are responsible for the activation of lymphocytes presen...
The Sankey diagram showed the corresponding gene group (Geneclusters A, B, and C) of each patient with CESC, the prognosis model m6A group, and the corresponding relationship among the survival statuses of patients (Fig. 3G). Simultaneously, survival analysis showed that the prognostic score ...
The development of single-cell detection platforms has enabled deep profiling of the heterogeneity of tumors and the immune system both within individual tumors and between patients [9, 10]. Genomic single-cell sequencing methods, which detect mutations at the DNA level, have been used to confirmed...
differentially used by moderate or severe COVID-19 patients compared with healthy controls and their intersections are shown with different colors. Venn diagram is used to show their overlaps with those published SARS-CoV-2 antibodies. Adjusted p values < 0.05 are indicated (two-sided unpaired ...
IIDB uses the MYSQL relational database system to store, retrieve and manage the data. The web interface between the user and IIDB is coded in PERL/CGI. Initially, the database was populated with a set of 1670 genes differentially regulated in response to LPS. We subsequently added a selec...
(A) Venn diagram of the three modules. Five common genes (JAM3, S100P, ARPC5, TRIM34, and GREB1L) were considered hub genes in one AF subtype. (B) Circos plot of the green and turquoise modules. Blue lines link the different genes and where they fall within the same ontology term....
a Schematic diagram of the cancer vaccine model. b Tumor volumes of C57BL/6 mice subjected to the cancer vaccination model were monitored overtime. The unimmunized group refers to mice without irradiated B16 cells immunization. The statistical significances between the immunized groups were indicated...