The immune system is distinctive for being a distributed system. It is not fixed to a single localized organ in the body, but rather is made up of numerous specialized cell types that must adaptably organize their intercellular connections to respond to pathogens and other threats wherever they ...
Mucosal immunityis considered the localimmune system, and the term implies regional limitation[1]. Themucosal immune systemis a complex network composed of innate cells, acquiredimmune cellsand their derivatives, which work together to protect its integrity through the cooperation of singlecell epitheliu...
The immune system is a sophisticated network of different cell types performing complex biocomputation at single-cell and consortium levels. The ability to reprogram such an interconnected multicellular system holds enormous promise in treating various diseases, as exemplified by the use of chimeric antig...
Antibodiesare complex, Y-shaped protein molecules that guard our bodies against diseases. The immune system's B lymphocytes, or B cells, develop into plasma cells, which can produce a huge variety of antibodies, each one capable of grabbing an invading molecule at the top ends of the Y. ...
P value was derived by a hypergeometric test. (G) Venn diagram showing integrated comparative analysis of upregulated DEGs in monocytes between YA and AA groups. Upregulated DEGs: upregulated in AA, downregulated in YA. The count showing the number of DEGs. (H) Representative GO terms and ...
differentially used by moderate or severe COVID-19 patients compared with healthy controls and their intersections are shown with different colors. Venn diagram is used to show their overlaps with those published SARS-CoV-2 antibodies. Adjusted p values < 0.05 are indicated (two-sided unpaired ...
effective manner [2]. We next explored the interaction between the CNS and the peripheral immune system after injury. Peripheral immune responses induced by stroke (Fig.1) Fig. 1 Schematic diagram of peripheral immune responses induced by hemorrhagic stroke ...
IIDB uses the MYSQL relational database system to store, retrieve and manage the data. The web interface between the user and IIDB is coded in PERL/CGI. Initially, the database was populated with a set of 1670 genes differentially regulated in response to LPS. We subsequently added a selec...
e, Venn diagram showing overlapping ChIP–seq binding regions shared between KDM5B and SETDB1. KDM5B only peaks, n = 25,315; Shared peaks, n = 66,503; SETDB1 only peaks, n = 16,934. f, Box plot showing RNA-seq log2 Fold Change (FC) of (Kdm5b-/- vs WT) for...
while tumor-resident only T clones were more exhausted.DVenn diagram showing the shared clonotype between different tissues, there are more shared CD8+T clones than CD4+T clones between tissues.E,FComparison of the clonality of CD4+and CD8+T cells in different tissue types. The CD8+T clones...