There is a growing awareness that tumor immune-escape is a complex process that involves many redundant mechanisms other than immune check-points. They interfere with the innate immune response, activation of adaptive immune response, homing of effector T cells, th...
Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanismsDavid Fernandez-Martinez, Youxin Kong, Sylvie Goussard, Agustin Zavala, Pauline Gastineau, Martial Rey, Gabriel Ayme, Julia Chamot-Rooke, Pierre Lafaye, Matthijn Vos, Ariel Mechaly & ...
Defining molecular mechanisms of immune subversion by HIV-1 and Mycobacterium tuberculosis However, these pathogens do not always operate independently and co-infection with both pathogens exacerbates the risk of lethality of either. Thus, a better understanding of the immune escape mechanisms of the tw...
Tumor-intrinsic mechanisms of immune escape in myeloma Tumor extrinsic mechanisms of immune escape in MM Tumor microenvironment suppression of immune responses Strategies to overcome immune escape in MM Conclusions Availability of data and materials Abbreviations References Acknowledgements Funding Author informat...
(X-rays, FLASH-RT, protons, carbon ion and radionuclides), biomarkers predictive of immune response, immune escape mechanisms elicited by IR and radioresistance. Importantly, the section welcomes translational and clinical studies assessing the combination of IR with immunotherapies (IT) with an ...
Escape from immune system recognition often involves tumor-specific genomic alterations in immune-related pathways, a process named genetic immune escape (GIE). GIE alterations operate through different mechanisms, including partial or complete abrogation of neoepitope presentation3 or suppression of pro...
Here, we used the framework of the cancer-immunity cycle to address the following questions: (i) what are the primary escape mechanisms in patients with either inflamed or noninflamed tumors that fail to respond to anti-PD-1 and anti-PD-L1 therapies? and (ii) why do some patients with ...
as well as a mechanisms by which tumors escape immune mediated killing. Accordingly, given the expression of Fas ligand on a variety of tumors, we and others have sought, and successfully demonstrated that FasL is expressed on exosomes secreted by tumor cells [71]. Due to the ability of exos...
Since it was now accepted that the immune system is capable of eliminating tumor cells, targeting of immune escape mechanisms employed by tumors is an appealing therapeutic strategy. These mechanisms can be broadly divided into three main categories: loss of antigenicity, loss of immunogenicity, and...
We discuss how common viral and cancer immune escape mechanisms can serve as a blueprint for improving the persistence of off-the-shelf allogeneic cell therapies. The prospects of harnessing genome editing and synthetic biology to design cell-based precision immunotherapies extend beyond programming ...