ILC2s-derived IL-9 could activate CD8 T cells to inhibit tumor growth, while anti-IL-9 reversed this effect. In vivo experiments showed that neutralizing ILC2s promoted tumor growth, while tumor inhibition occurred by intravenous injection of IL-9. In conclusion, our results demonstrated that ...
Effects of IL-9 and IL-9-stimulated CD8 T cells on CT26 cells were measured by proliferation, apoptosis, and migration assays in vitro. GEPIA was used to detect the ILC2s chemokines in CRC tissue and adjacent normal tissue. Results We found that ILC2s were increased in CRC tissue compared...
IL⁃25和IL⁃33等刺激下能够产生IL⁃4㊁IL⁃5㊁IL⁃9和IL⁃13等Th2型细胞因子,在自身免疫病㊁抗感染和体内免疫平衡中发挥重要作用㊂本文综述了ILC2在炎症性疾病发展过程中的免疫学特性及其发挥的作用,及脏器局部微环境改变对ILC2的影响,为进一步了解ILC2参与的炎症性疾病发病机制及相关治疗提供...
在过去几十年一直认为2型炎症型哮喘与由CD4+T 细胞分化的2型辅助性T 细胞（T helper type 2，Th2）密切相关，它分泌大量白介素-4（interleukin-4，IL-4）、IL-5和IL-13在内的促炎细胞因子，称这种哮喘为“Th2型哮喘”（2型炎症型哮喘），Th1/Th2细胞的失衡早已被认为是“Th2型哮喘”的发病机制[3]。
Immunity to many human and murine gastrointestinal helminth parasites requires interleukin-4 (IL-4)-directed type 2 helper (TH2) differentiation of CD4+ T cells to elicit type-2 immunity. Despite a good understanding of the inflammatory cascade elicited following helminth infection, the initial...
IL-13在特应性皮炎发病机制中起重要作用,特应性皮炎皮损也显示角质形成细胞来源的IL-25表达增加,2型固有淋巴细胞(ILC2)数量增加。Leyva-Castillo等分享了一些研究结果,证明IL-25激活ILC2对于过敏性皮肤炎部位IL-13的表达至关重要。 ...
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实验证实,蛋白酶过敏原诱导的肺部炎症中,ILC2是IL-5、IL-13的早期关键来源,且不依赖T细胞。也有研究发现,在蛋白酶诱导的早期模型中ILC2产生IL-9且其产生是必要的[25]。使用中和抗体来阻塞IL-9,可导致IL-5 与IL-13 表达减少,提示ILC2 可能先产生IL-9,成熟后产生IL-5 和IL-13。 2.3.3 真菌过敏性哮喘 ...
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