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参考文献:Aletaha D, Kerschbaumer A, Kastrati K, et al. Consensus statement on blocking interleukin-6receptor and interleukin-6 in inflammatory conditions: an update. Ann Rheum Dis. 2022 Aug 11:annrheumdis-2022-222784. 声明:本文出自医会宝编...
1，IL-6-mediated signaling events 2，VEGFR3 signaling in lymphatic endothelium 3，Angiopoietin receptor Tie2-mediated signaling 4，Signaling events mediated by TCPTP 5，而在4条显著变化的通路中，IL-6介导的信号通路变化最显著。乳腺癌患者DCCs细胞拷贝数变异（Nat Commun . 2020）进一步的研究发现受体VEGFR...
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IL-6是一个小分子糖蛋白，分子量为19-28kDa，由184个氨基酸形成四个α螺旋结构，通常以单体形式存在，等电点为5.0。编码人IL-6的基因位于染色体7p15-21，包括4个内含子和5个外显子。IL-6有3个受体结合位点，包括1个特异性受体IL-6R (IL-6 binding receptor protein，IL-6R）结合位点，和2个gp130（...
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在人体染色体7p15-21上存在编码IL-6的基因,其中包含内含子(4)和外显子(5)。IL-6有3个受体结合位点,包括1个特异性受体IL-6R (IL-6 binding receptor protein,IL-6R)结合位点,和2个gp130。(signal-transducing protein)结合位点。 图1 IL-6蛋白结构示意图...