The IL-6 receptor system consists of two membrane proteins, a ligand-binding chain (IL-6R) and a non-ligand-binding signal transducer, gp130, both of which belong to the cytokine receptor family. Binding of IL-6 to IL-6R triggers the association of IL-6R and gp130, and gp130 in ...
上海玉博生物科技有限公司 主要致力于“Human IL-6 Receptor peprotech-200-06R-1mg”的生产销售。多年的“Human IL-6 Receptor peprotech-200-06R-1mg”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深受广大用户信赖。欢迎来电咨询或前
The gp130 chain of the IL-6 receptor is endogenously expressed. They were further transfected with a STAT3-inducible secreted embryonic alkaline phosphatase (SEAP) reporter. The binding of IL-6 to its receptor triggers a signaling cascade leading to the activation of STAT3 and the subsequent ...
soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126 Description : IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. The IL-6Rα chain is the binding component specific to IL-6; while the gp130 onl...
IL-6 是由单核/巨噬细胞、内皮细胞、脂肪细胞和造血细胞等细胞产生的一种多效性细胞因子,广泛作用于 T 细胞、B 细胞、巨噬细胞、肝细胞、血管内皮细胞和造血干细胞等多种细胞类型,在炎症调控、免疫反应及造血过程中发挥关键作用, 其临床检测是炎症诊断的重要指标[31]。
“An isolated antibody to human interleukin-6 receptor, wherein said antibody specifically binds to said human interleukin-6 receptor.” US5670373A的权利要求1的保护范围相当宽泛,仅限定了抗体的结合靶标,未限定抗体种类 (可以是单克隆或多克隆抗体)、结构或性质。结合研发历史,我们知道Kishimoto等人首次克隆得...
别名:IL6R; CD 126; CD126; CD126 antigen; gp80; IL 6R 1; IL 6R alpha; IL 6R; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; Il6r; IL6RA; IL6RA_MOUSE; Interleukin 6 receptor alpha chain; Interleukin 6 receptor; Interleukin-6 receptor subuni...
The human IL-6 is a single non-glycosylated polypeptide chain containing 183 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain (CD126), and the signal- transducing component gp130 (also called CD130). The human...
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays critical roles in regulating inflammation, hematopoiesis, metabolism, and oncogenesis [1]. Classic IL-6 signaling is initiated by the binding of IL-6 to the membrane-bound IL-6-specific receptor α chain (IL-6R). The IL-6/IL-6R...
6,7 Although expression of mIL-6R is restricted, being found primarily on hepatocytes and some leukocyte subsets, IL-6 also interacts with soluble IL-6R (sIL-6R), which on binding to its ubiquitously expressed gp130 co-receptor can activate a variety of cells (IL-6 trans-signaling). ...