The last three residues of YPELPK, Leu-Pro-Lys, were found to be critical for the binding of the peptide to hnRNP M.The biological activity of YPELPK and its Ala-scan analogs was studied using differentiated human THP-1 cells, which express hnRNP M on their surface and secrete IL-6 ...
H. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436, 1186–1190 (2005). Article CAS Google Scholar Soriani, A. et al. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in ...
2021). Several mechanisms are involved in this function, (1) MSCs reduce apoptosis of vascular endothelial cells and subsequently the vessel injury and disseminated intravascular coagulation (DIC) through decreasing the expression of pro-inflammatory cytokines such as TNF-α, IFN-γ, IL-6. (2) ...
inhibitory checkpoint system has been the programmed cell death protein-1 (PD-1)/PD-1 ligand-1 (PD-L1) pathway. For instance, the PD-1/PD-L1 pathway suppresses many functions of T and NK cells, e.g., their proliferation and cytotoxic activity (Buckle and Guillerey2021; Baldanzi2022)....
96. Excessive accumulation of immune cells in the gut and induction of complex inflammatory networks make it difficult to explain the roles of individual cytokines and immune pathways as well as the precise etiology and the pathogenesis of IBD97. Interleukin-1b, IL-6, IL-8, and TNF stimulate...
Furthermore, BEND cells express the mRNA of various P2Y receptor subtypes, which could be key contributors to bovine endometrial inflammation.Manganese, a trace element that is essential for physiological function in both animals and humans, should be supplied through their diet. The consumption of ...
3.2. S49 Cells Predominantly Express mRNA for sstr2 In the absence of specific antibody reagents, we tested for expression of mRNA for each receptor subtype by RT-PCR. With specific primers for sstr2, amplified bands indicative of expression of sstr2A and sstr2B mRNAs were detected (Fig. ...
cells in the mouse brain under homeostasis and analyzed the expression ofCasp4expression levels in this scRNA-seq atlas [32]. In agreement with our findings, we found thatCasp4is mainly/highly expressed by microglia which also highly express CX3CR1 (Supplementary Fig.1). Therefore, we ...
2015;15(6):869–79. Article CAS PubMed Google Scholar Asfaha S, Dubeykovskiy AN, Tomita H, Yang X, Stokes S, Shibata W, et al. Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis. ...
do not recognize HLA matched tumor cells which express MAGE-1 endogenously. There have been two explanations proposed for this. One is that the peptides at issue are not generated efficiently by the cells. The second is that the CTLs obtained using high concentrations of the synthetic peptides...