[13] Tilley, Jefferson W., et al. "Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2." Journal of the American Chemical Society 119.32 (1997): 7589-7590.[14] Zhang, Bo, et al. "Proximity-enabled covalent binding of IL-2 to...
OBX-115 autologous engineered TIL cell therapy does not require co-administration of IL2 due to its regulatable expression of membrane-bound IL15 (mbIL15) using the FDA-approved small-molecule drug acetazolamide (ACZ) to provide cytokine support for TIL expansion and persistence.Methods:This Phase ...
cytokineadjuvant. Theresults provide referencedataforthenew generation vaccineresearchofPPVand PCV2. Key words:PorcineParvovirus;PorcineCircovirus;VP2gene;ORF2gene:IL一2 目录 综述部分………1 1猪细小病毒的生物学特性………1 2PPVVP2基因及其编码蛋白的功能……...
In this study, human mesenchymal stem cells were genetically modified to overexpress human interleukin-2 (IL2), a cytokine which regulates the proliferation and activation of immune cells. Membrane vesicle release from native and genetically modified stem cells was induced by cytochalasin B treatment ...
Colony-stimulating factor 2 (CSF2) is deemed an essential cytokine by preclinical studies, exhibiting a causal link to atherosclerosis and cancer. A study of serum anti-CSF2 antibody levels was conducted on patients simultaneously experiencing atherosclerosis and/or solid cancer.We examined the serum...