IFN-α and IL-12 induce IL-18 receptor gene expression in human NK and T cells. J Immunol 2000;165:1933-8.SarenevaT,JulkunenI,MatikaninenS.IFNα andIL-12 induceIL -18receptor gene expression in humanNK andT cells.JImmunol. ... T Sareneva,I Julkunen,S Matikainen - 《Journal of Im...
Adv Cell Gene Ther. IL-18的应用问题 尽管理论上IL-18可以在“热”肿瘤以及“冷”肿瘤中发挥其广泛的免疫刺激活性,但实际药物开发中却发现,采用和其他细胞因子相同策略的重组IL-18疗法对于各类适用免疫疗法的肿瘤基本都无效。 天然IL-18抗癌活性较弱,是由于肿瘤会产生高水平...
Gene Accession: Purity: Expression system: Tags: Background: Interleukin 18 receptor accessory protein ACPL; CD218b; IL18RB; CDw218b O95256 BC106765 >85%, as determined by Coomassie blue stained SDS-PAGE Escherichia coli His tag C-Terminus, GST tag N-Terminus Interleukin 18 receptor accessor...
Four structurally related IL1 receptor ligands have been described. These include three agonists designated IL1α, IL1β and IL1γ/IL18 and a specific receptor antagonist, IL1Rα. IL1α and IL1β play critical roles in the regulation of the immune response...
IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and istherefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests ...
This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this...
Background:The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this...
cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene....
An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5,
Interleukin 18 Receptor beta Entrez Gene IDs 8807 (Human); 16174 (Mouse) Alternate Names Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b antigen; CD218b; CDw218b; IL-1 R7; IL-18 R beta; IL-18 receptor accessory protein; IL-18 receptor beta; IL18R beta...