Rene 等发现[6],内源性与外源性IL-10 均能在转录水平强烈抑制白介素 1( interleukin-1, IL-1) 、IL-6、IL-8、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α) 、粒-巨噬细胞集落刺激因子( granulocyte-macrophage colony stimulating factor, GM-CSF) 和粒细胞集落刺激因子( granulocyte colony-...
IL-1) 、IL-6、IL-8、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α) 、粒-巨噬细胞集落刺激因子( granulocyte-macrophage colony stimulating factor, GM-CSF) 和粒细胞集落刺激因子( granulocyte colony-stimulating factor, G-CSF) 的合成,从而起到抗炎的作用。
Hu X, Chen J, Wang L, Ivashkiv LB (2007)Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation.J Leukoc Biol82(2):237-43.Epub 2007 May 14.Review. Cavalcante LB, Tanaka MH, Pires JR, et al.(2012)Expression of ...
Tumor cell-derived TGF- and IL-10 dysregulate paclitaxel-induced macrophage acti- vation. J. Leukocyte Biol. 69: 129 -137.Mullins DW,Martins RS,Burger CJ,et al.Tumor cell-derived TGF-beta and IL-10 dysregulate paclitaxel-induced macrophage activa-tion. Journal of Leukocyte Biology . 2001...
5 Macrophage involvement in MC38 tumor model. a, b, Macrophage depletion was performed by injection of liposomal clodronate on day −1 and day 6 after MC38 inoculation in WT or muMt-/- mice. Tumor volume was monitored at the indicated time points (n = 9 (WT control liposomes), ...
(tumor associated macrophage, TAM) 产生 IL 10 和 TGF β 能力的增强不依赖 MyD88 Toll 样受体(TLR) 信号通路,而TLR 介导细胞外调节蛋白激酶(ERK) 1 / 2 丝裂原活化蛋白激酶( MAPK) 激活是 IL 10 和 IL 12 在TAM 中产生的一个关键的调解途径。 实验 ...
Clinicopathological significance of peritumoral alveolar macrophages in patients with resected early-stage lung squamous cell carcinoma Authors - Yu Tanaka View Article pig Curr Issues Mol Biol Transcriptomic Establishment of Pig Macrophage Polarization Signatures Authors - Jing Li View Article Cancer Cell ...
Macrophage Activation Markers Microglia Activation Markers Microglia Homeostasis Molecules Secreted by VSMC Monocyte Markers Multiple Sclerosis and Myelin Related Molecules Myeloid-derived Suppressor Cells (MDSC) Natural Killer T (NKT) Cells Neuroinflammatory Factors ...
Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Tr...
Inhibit IFN-γ, TNF-β, IL-2 production by TH1 clones; inhibits macrophage-mediated IL-1, IL-6, TNF-α synthesis; suppress delayed type hypersensitivity response; stimulate TH2 cell response; mast cell proliferation in Cell Sources Activated CD8+ and CD4+ T cells, activated monocytes, mast...