Interleukin-1beta and receptor antagonist (IL-1Ra) gene polymorphisms and the prediction of the risk of end-stage renal disease. Biomarkers 2006; 11: 164-173.Interleukin-1beta andreceptor antagonist(IL-1Ra)gene polymorphisms and the predictionof the risk of endstage renal disease. Manchanda P K...
IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest. 2012 Oct;122(10):3476-89.[2]. Karina Zitta, et al. Interleukin-1beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in cultured primary pig heart cells...
and initiating acute-phase responses. Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory...
(interleukin-1 receptor,IL-1R)包括Ⅰ型和Ⅱ型,此外还存在一种内源性IL-1受体拮抗剂 (interleukin-1 receptor antagonist,IL-1ra或IL-1Y),IL-1ra可以与IL-1受体结合,但是不引起相应的作用.炎症情况下,粒细胞巨噬细胞集落刺激因子(GM-CSF) 水平升高,它也能促进IL-1 的上调作用,增加IL-1B的合成;另外关节...
IL-1R antagonist binds to IL-1R type I without inducing a response, which blocks the binding of IL-1β to the receptor. Interaction Multiple cells. Ligand/Receptor Type I and II IL-1 receptors (IL-1RI and IL-RIII). Cell Type Hematopoietic stem and progenitors Biology Area ...
[1]. Jan Petrasek, et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest. 2012 Oct;122(10):3476-89. [2]. Karina Zitta, et al. Interleukin-1beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in...
Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1 beta ...
(IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing ...
be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and ...
[1]. Jan Petrasek, et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest. 2012 Oct;122(10):3476-89. [2]. Karina Zitta, et al. Interleukin-1beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in...