炎症刺激还会驱动含有 CARD 和 PYHIN 结构域的 PRR 的激活,这些 PRR 会募集 ASC 和caspase-1(Casp-1) 组装成多蛋白复合物炎症小体。Pro-Casp-1(由 pro-Casp-1 编码)由炎症小体激活,将 pro-IL-1β 裂解为具有生物活性的 IL-1β。IL-1β 通过 I 型IL-1受体 (IL-1R1) 以自分泌/旁分泌方式发挥...
IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex ...
IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex ...
IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex ...
The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of...
Size1 Plate Kit, 2 Plate Kit, 5 Plate Kit SpeciesHuman Accession NumberP01584 Gene Id3553 Gene SymbolsIL1B|IL1F2 Protein Name / SynonymsInterleukin-1 beta (IL-1 beta) (Catabolin) Quantitative/Semi-QuantitativeQuantitative SpecificityThis ELISA kit shows no cross-reactivity with any of the cyt...
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Mutations within the NALP3/cryopyrin/CIAS1 gene are responsible for three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and CINCA. The NALP3 protein is homologous to NALP1, which is a component of the inflammasome, a molecular platform that activates the...
IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex ...
As shown in Figure 6A, a luciferase reporter gene assay showed that FMDV infection significantly increased NF-κB promoter activation compared with the control. Consistently, NF-κB mRNA levels and p65 phosphorylation were also increased after FMDV infection. Together with Figure 1D,E, the results ...