Dual TNFα/IL-4 inhibitorMolecular simulationNetwork analysisAtopic dermatitis (AD) is a common inflammatory skin disease involving multiple signaling pathways. One of the effective treatment strategies of AD is to develop a new drug capable of regulating the key therapeutic targets. Here we report ...
In addition, flow cytometric analysis demonstrated that a STAT6 inhibitor counterregulated the upregulation of cell surface levels of the protein GGT5 induced by IL-5 and by both IL-5– and the cell surface levels of the proteins IL1RL1 and IL3RA induced by IL-4 (Fig 5, B). These re...
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Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-κB activation. FEBS Lett. 413, 354–358 (1997). CAS PubMed Google Scholar Sigal, N. H. et al. Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? J. Exp....
Phosphorylated inhibitor of kappa B PKC: Protein kinase C SDS: Sodium dodecyl sulfate Sub: Subcutaneous layer Th: T helper TNF-α: Tumor necrosis factor-alpha References Leung DY, Bieber T. Atopic dermatitis. Lancet. 2003;361(9352):151–60. Article PubMed Google Scholar Bantz SK,...
Baricitinib (BARI) is an orally administered small molecule, a selective inhibitor of JAK1 and JAK2 tyrosine kinases. Recently, the drug was approved in Europe and Japan in adult patients with moderate-to-severe AD at both 4 and 2 mg oral daily dosage [64,65]. The efficacy and safety of...
The second band for IL-4Rα at 90 kDa was shown to be the non-glycosylated IL-4Rα by incubation of Capan-1-cells with Tunicamycin, an inhibitor of N-linked glycosylation (Figure S1A). In order to test the in vitro and in vivo influence of IL-4Rα on pancreatic cancer cells, we...
纤维数量明显减少,心肌纤维 横径增宽 ,心肌胞浆着色不均 ,颜色深浅不一 , 心肌细胞间连接松散,心肌纤维完整性及连续 性较差;黄芪甲苷组小鼠心肌纤维出现不同程 度的染色不均,但与模型组比较该情况有所减 ·7340· 中草药 2024 年 11 月第 55 卷第 21 期 Chinese Traditional and Herbal Drugs 2024 ...
AAV9-HGF combined with a TGF-β/SMAD inhibitor reduces silicosis fibrosis by suppressing ferroptosis [22]. However, it is unknown whether SMAD4 influences the development of asthma by regulating ferroptosis. Interleukin 17 (IL-17), also referred to as IL-17 A, is a pro-inflammatory cytokine ...
inflammatory factors leading to eosinophilia. Furthermore, the bromodomain and extraterminal domain (BET) inhibitor synergized with standard-of-care drugs for ALL, effectively reducing IL-3 expression and inhibiting ETV6::ACSL6 ...