Interleukin-2 and the IL-2 receptor: new insights into structure and function. J Invest Dermatol. 1990 Jun;94(6 Suppl):27S-32S. doi: 10.1111/1523-1747.ep12875017. PMID: 1693645. [11].Schneider A, Gorr IH, Larraillet V, Frensing T, Popp O. Reduction of IL-2 fragmentation during ...
X. Wang, M. Rickert, K.C.Garcia, Structure of the quaternary complex of interleukin-2 with Its α, ß, andγc Receptors. Science (80-) 310 (2005) 1159 LP–1163 Lafreniere R, Rosenberg SA.1985. Successful immunotherapy of murine experimental hepatic met...
HUMAN IL-2 structure CAS No. 110942-02-4 Chemical Name: HUMAN IL-2 Synonyms IL-2;HIL-2;C07903;RHIL-2;HUMAN IL-2;HUMAN TCGF;TCGF HUMAN;IL-2, HUMAN;aldesleukin;IL-2 from rat CBNumber: CB3161838 Molecular Formula: Molecular Weight: 0 MDL Number: MFCD00165721 MOL File: ...
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X. Wang, M. Rickert, K.C.Garcia, Structure of the quaternary complex of interleukin-2 with Its α, ß, andγc Receptors. Science (80-) 310 (2005) 1159 LP–1163 Lafreniere R, Rosenberg SA.1985. Successful immunotherapy of murine experimental hepatic metastases withlymphokine activated kil...
1976年发现的IL-2,在整个免疫治疗史上,有着不可替代的位置。Rosenberg称之为第一个人类肿瘤有效的免疫治疗方法。IL-2/IL-2R受体里程碑研究 1976年 NCI肿瘤细胞生物学实验室的RobertGallo,使用PHA刺激淋巴细胞产生条件培养基培养骨髓细胞,其中90%的T细胞长达9个月的生存维持。在此之前,原代T细胞无法体外培养,是免疫...
Trotta, E. et al. (2018) A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med.24, 1005–1014 LaPorte, K.M. et al. (2023) Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumorspecific CD8(+...
Rang,Y,Lee,N,Liang,S.M.Analysis of IL-2 functional structure by multiple cysteine substitutions. Biochemistry and Biophysics . 1992Rong et al., " Analysis of IL-2 functional structure by multiple cysteine substitutions, " Biochemical and Biophysical Research Communications, 188(2): 949-955, ...
Of all the lympho-kine-receptor systems in immunology, perhaps most is known about the structure, function, and binding properties of IL-2 and its cognate receptor. There are two distinct, membrane-associated IL-2 binding components in the high-affinity IL-2 receptor: an α subunit and a ...