il-17 signaling pathway翻译 il-17signalingpathway翻译：IL-17信号通路
翻译:北医三院刘佩玲 摘要:白介素17(IL-17)和低氧已被认为在类风湿关节炎(RA)中起着关键作用。在该研究中,在RANKL和M-CSF存在下,IL-17和氯化钴(CoCl2)(一种缺氧模拟物)的联合处理显著增加了破骨细胞形成以及RAW 264.7巨噬细胞中TRAP和MMP-9的表达。IL-17和CoCl2的统一作用通过RANKL/NF-κB/NFATc1信号通路...
intheproliferationandmetastasisofgastriccancerandthemechanismofactioninangiogenesis,providingnewideasfortheindepthstudyoftheroleofIL17anditsrelatedsignalingpathwaysintheoccurrenceanddevelopmentofgastriccancerandtheclinicaldiagnosisandtreatmentofgastriccancer. [Keywords]gastriccancer;inflammatoryimmunity;IL17;signalingpathway...
Conclusion The hub genes,such as CCL20,may play a key role in promoting the inflammatory progression of DN through regulating the IL-17 signaling pathway,which contribute to identifying potential biomarkers and therapeutic targets for DN.糖尿病肾病(DN)是终末期肾病(ESRD)的最常见病因,也是慢性肾脏病...
Fig.2 Signaling pathway of IL-17 施沛青等: IL-17的信号传导及功能研究 349 导的下游基因中得到了线索。IL-17A诱导的基因表 明它是一个促炎症因子, 跟IL-1Rs与TLRs受体类似, IL-17A也通过激活NF-kB [3] 、MAPK [33] 诱导下游基 因。但IL-17A只能微弱地激活NF-kB, 通过基因芯 ...
was activated. We hypothesize that the patient with SLEDAI score lower or low activity index of renal pathology in patients with LN, the therapy with the inhibitor of mTOR signaling pathway might be more significant.【Key words 】 Lupus nephritis;p -S6;IL -17;MTOR signaling pathway ...
Objective To observe the effects of interleukin-17A (IL-17A) on the secretion of keratin 17 (K17) from human immortalized keratinocyte cell line (HaCaT) cultured in vitro and the signal transducer and activator of transcription 3 (STAT3) signaling pathway,and to provide a theoretical basis fo...
Th17 cells are thought to interfere with glutamate signaling, dopamine production, and other immune processes. Ketamine is a newly characterized antidepressant medication which has proved to be effective in rapidly reducing depressive symptoms. However, the mechanisms behind these antidepressant effects have...