Licinio, "Interleukin (IL) 1𝛽, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications," Proceedings of the National Academy of Sciences of the United States of America, vol. ...
白细胞介素-1(interleukin-1,IL-1)是在感染和炎症状态下,由多种细胞产生的、有多方面生物学功能的细胞因子,其生物学作用十分广泛,主要包括参与介导炎症反应、调节免疫、调节机体代谢.IL-1分子重量为17.5KD,有两种类型:IL-1a和IL-1B,主要以IL-1B为主.IL-1受体(interleukin-1 receptor,IL-1R)包括Ⅰ型和Ⅱ型...
Background Interleukin 1 (IL-1) and its physiological antagonist interleukin-1 receptor antagonist (IL-1ra) play a crucial role in the pathogenesis of inflammatory bowel disease. Polymorphisms in the genes coding for these cytokines, the restriction enzyme TaqI polymorphism for IL-1beta and the var...
小鼠白细胞介素1beta检测试剂盒IL-1 RII对IL-1β具有较高的亲合性,但作为诱捕受体(decoy receptor)发挥功能,负调控IL-1β的活性。IL-1ra作为竞争性抑制剂发挥作用,阻止IL-1α 和 IL-1β与IL-1 RI相互作用。小鼠IL-1β的cDNA编码一个由269个氨基酸残基组成的前体蛋白,117个氨基酸残基在胞内由半胱氨酸蛋白...
While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its ...
The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful ...
3.Brikos C, Wait R, Begum S, O'Neill LA, Saklatvala J. Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol Cell Proteomics. 2007 Sep;6(9...
and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 ...
IL-1RL1蛋白; IL-1 R4蛋白; Recombinant Mouse IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4 (C-Fc)价格:价格电议产品详情:公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服... 包装规格:10ug 货号:abs04497 品牌:爱必信(absin) ...
we first identified with immunocytochemistry and Western blot methods that interleukin-1 receptor type I was expressed in the PC12 cells. We then demonstrated with patch clamping technique that extracellular application of IL-1 beta dose-dependently inhibited the outward voltage-dependent and TEA-...