近日,Signal Transduction and Targeted Therapy杂志上发表了华中科技大学袁响林教授和王玮教授团队的一项研究,其研究结果表明使用托西珠单抗阻断IL6/JAK2/STAT3通路抑制M2小胶质细胞活化可降低NSCLC患者BM发生率。 研究背景 关于BM机制研究的重...
总的来说,本文通过细致的研究阐述了应激诱导的IL-6对机体功能的机制:急性应激引起交感神经输出,激活肾上腺素受体3后促进IL-6水平的升高,随后增强肝脏合成葡萄糖的能力,为逃避或战斗储备能量。 论文链接:https://doi.org/10.1016/j....
2002. Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells. Leukemia 16:1182.Cheung WC, Van Ness B. Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell ...
Expression of IL-6 and IL-6 receptors by circulating clonotypic B cells in multiple myeloma: potential for autocrine and paracrine networks. Exp Hematol 2001; 29:1076-81.6. Frassanito MA, Cusmai A, Iodice G, Dammacco F. Autocrine interleukin-6 production and highly malignant multiple myeloma...
IL-6 and disease (4)诊断价值 (5)1980年白介素-6（interleukin 6, IL-6）被Weissenbach发现，命名为β2 干扰素，在之后的研究中IL-6不断被其他人发现并先后命名为杂交瘤/浆细胞瘤生长因子、B 细胞生长因子，肝细胞刺激因子等，直到这些细胞因子的基因被克隆出来后，才命名为IL-6。IL-6是一种多功能细胞...
Jaks and Stats are critical components of many cytokine receptor systems; regulating growth, survival, differentiation, and pathogen resistance. An example of these pathways is shown for the IL-6 (or gp130) family of receptors, which coregulate B cell differentiation, plasmacytogenesis, and the ...
基因别名 :Il-6, Il6 基因ID :(Mouse) 16193 基因符号 :Il6 蛋白别名 :B-cell hybridoma growth factor, IL-6, Interleukin HP-1, H-IL-6, ILN, Interleukin, Interleukin6, M-IL-6, R-IL-6, Interleukin-6 UniProt ID(Mouse) P08505
显色剂B液 3 ml×1 瓶 6 ml×1 瓶 2-8℃保存 终止液 3ml×1 瓶 6ml×1 瓶 2-8℃保存 浓缩洗涤液 (20ml×20 倍)×1 瓶 (20ml×30 倍)×1 瓶 2-8℃保存 样本处理及要求: 1. 血清:室温血液自然凝固10-20 分钟,离心20 分钟左右(2000-3000 转/分)。仔细收集上 ...
之前有研究发现,敲除PER2蛋白可有效减轻特异性皮炎症状如皮肤中促炎因子(IFN-γ、IL-1b)的含量减少,且敲入PER2蛋白会加重特异性皮炎症状。 IL-4是一种II型炎症因子,在特异性皮炎的发病机制中起到核心作用。IL-4可增强PER2蛋白在皮肤中的表达程度,这进一步揭示了人体的炎症反应和昼夜节律存在一定的联系。基于以上...
Chalaris, A., Garbers, C., Rabe, B., Rose-John, S. & Scheller, J. The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. Eur. J. Cell Biol. 90, 484–494 (2011). CAS PubMed Google Scholar Jones, S. A. Directing transition from innate to acquired ...