437 IL-17C inhibition reduces skin inflammation in IL23-induced psoriasis mouse modelBackground Non-selective Janus kinase (JAK) inhibitors have shown long-term efficacy in treating rheumatoid arthritis (RA). However, tolerated doses and thereby efficacy are limited due to JAK2-driven side effects....
In this report we describe a novel mouse model of PS and PsA induced by selective and conditional expression of IL-23 in the skin (K23mice). Upon expression of IL-23, the animals developed a skin inflammatory disease that presented hallmarks of psoriasis such as acanthosis, parakeratosis, cel...
437 IL-17C inhibition reduces skin inflammation in IL23-induced psoriasis mouse model 来自 Semantic Scholar 喜欢 0 阅读量: 131 作者: Marsais, F,Auberval, M,Lavazais, S,Lepescheux, L,Clement-Lacroix, P,Dupont, S,Haertle, S,Steidl, S,Brys, R,Vandeghinste, N 展开 ...
ly transferred B1 B cells directly suppressed the symptoms of IL-23-mediated psoriasis-like inflammation. Thus, Bregs play a critical role in suppressing IL-23-mediated psoriasis-like inflammation. In a mouse model of imiquimod-induced psoriasis-like inflammation, Bregs also play an important role...
Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice. Authors:Chamcheu JC, Adhami VM, Esnault S, Sechi M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SM, Chaves-Rodrique...
IL-23 is generally considered a pro-inflammatory cytokine since 2006, primarily produced by cells of the mononuclear phagocyte system. IL-23 drives the pathophysiology of immune disorders, such as psoriasis and inflammatory bowel disease, by inducing a pathogenic lymphocyte program promoting tissue infla...
In the calcipotriol-induced AD model, ear skin inflammation, TSLP and IL-33 protein production in ears was suppressed by MOR106. Consistently, in the flaky tail strain mouse model, spontaneous development of AD-like skin inflammation was reduced by MOR106. Moreover, serum IgE levels, number ...
“Regulation of Virus-Induced IL-12 and IL-23 Expression in Human Macrophages” Journal of Immunology, (2002) pp. 5673-5678. Piskin, G., “Clinical Improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-y ...
Moreover, we used an IL-23-induced psoriasis-like mouse model to confirm these results. CCN1 knock down with a lentiviral vector expressing shRNA (pLVX-iCCN1) significantly decreased the ear thickness (Fig. 6a). The H&E staining data showed decreased epidermis thickness in ears of pLVX-...
muridarum CMC Staphylococcal diseases Excessive inflammation Mouse Oral cavity Skin Vagina Intestine Lung Human Oral cavity Skin Vagina Intestine Lung IL-23- or imiquimod-induced psoriasis-like skin inflammation TPA-induced psoriasis-like legions in K5.Stat3C transgenic mice TNBS-induced colitis DSS-...