T helper (Th) 17 cells and secreted interleukin (IL)-17A contribute to its pathogenesis. IL-17A treated STAT3 overexpressing mouse model might serve as an animal model for psoriasis. Methods: In this study, we established a mouse model of psoriasiform dermatitis by intradermal IL...
Figure 2. Impact of the IL-23/IL-17 pathway on epidermal keratinocytes in psoriatic skin.[4] Cyagen has developed theB6-hIL-17A humanized mouse model (Product Code: C001510)for research on targeted therapies against IL-17A.This model was successfully established as a psoriasis model using ...
Psoriasis vulgaris is the best-understood and most accessible human disease that is mediated by T cells and dendritic cells. Inflammatory myeloid dendritic cells release IL-23 and IL-12 to activate IL-17-producing T cells, Th1 cells, and Th22 cells to produce abundant psoriatic cytokines IL-17...
Research into the pathogenesis of psoriasis has profited from suitable animal models. Previously, we reported on the CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis, which is characterized by reduced expression of the common chain of β2-integrins (CD11/CD18) ...
Although the association between IL-17 and IgA in psoriasis has not been previously reported to our knowledge, the link between IL-17 and Igs has been previously described in animal models. IL-17 deficient (IL-17−/−) mice showed impaired Ig response in allergic (Nakae et al., 2002)...
In addition to IL-23 and IL-17, IL-22 has also been reported to induce cutaneous inflammation in an experimental murine model of psoriasis and has also been shown to induce in vitro an inflammatory-like phenotype in vitro (Van Belle et al. [2012]). IL-22 is a member of the IL-10 ...
16,17 The SIRs were treated as HRs.26 The pooled HRs and corresponding CIs were synthesized by using the random-effects model based on the assumption of considerable clinical heterogeneity.27 Between-study heterogeneity was quantified using the I2 statistic, with an I2 of greater than 50% ...
We have also shown that ozone therapy can significantly inhibit inflammatory-related pathways, such as NF-κB, TLR, TNF, and IL-17, in a psoriasis animal model. These data provide an insight into the mechanisms underlying the therapeutic effects of ozone therapy on psoriatic lesions....
In an animal model, IL-17A overexpression in keratinocytes was shown to induce systemic vascular inflammation, endothelial dysfunction, and arterial hypertension [17]. Another animal study showed that IL-17 induces hypertension by decreasing endothelial NO production [32]. In psoriasis, neutrophils ...
Therefore, IL-17A inhibition by the anti-IL-17A biologic results in early clinical, histopathologic, and molecular resolution of psoriasis [69]. In addition, various murine psoriasis models stress a pivotal role of the IL-23/IL-17A axis in experimental psoriasis [76–80]. Multiple animal ...