Murine IL-23 induced model of inflammation corresponds to the human psoriasis phenotype: Statistically significant overlap of DEGs and ranked gene lists.Mayte, SuárezFariñas
In this report we describe a novel mouse model of PS and PsA induced by selective and conditional expression of IL-23 in the skin (K23mice). Upon expression of IL-23, the animals developed a skin inflammatory disease that presented hallmarks of psoriasis such as acanthosis, parakeratosis, cel...
ly transferred B1 B cells directly suppressed the symptoms of IL-23-mediated psoriasis-like inflammation. Thus, Bregs play a critical role in suppressing IL-23-mediated psoriasis-like inflammation. In a mouse model of imiquimod-induced psoriasis-like inflammation, Bregs also play an important role...
The AMPs are expressed in the epidermis, and may play an important role in psoriasis pathogenesis, because they are strongly induced by the IL-17 family and may create feedforward pathways of immune activation [75]. When plasmacytoid dendritic cells (PDCs) are activated by cathelicidin ...
437 IL-17C inhibition reduces skin inflammation in IL23-induced psoriasis mouse model 来自 Semantic Scholar 喜欢 0 阅读量: 131 作者: Marsais, F,Auberval, M,Lavazais, S,Lepescheux, L,Clement-Lacroix, P,Dupont, S,Haertle, S,Steidl, S,Brys, R,Vandeghinste, N 展开 ...
Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice. Authors:Chamcheu JC, Adhami VM, Esnault S, Sechi M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SM, Chaves-Rodrique...
One of the immediate response psoriasis factors, CCL20, is upregulated by synergistic IL17/TNF signaling and attracts clusters of CCR6+ dendritic cells and T cells to the psoriatic epidermis.26,27 Administration of anti-CCL20 antibodies in a murine model reduce IL23-induced, psoriasiform ...
psoriasiform model is not clear.ObjectivesTo investigate the role of IL-10 in the IMQ-induced psoriasis-like skin inflammation.MethodsPsoriasis-like skin inflammation was induced by topical application of imiquimod (Aldara) for 5 or 10 ... X Xu,E Prens,E Florencia,... - European Workshop fo...
6g:They classified these DEGs into 4 group:“eTreg signatures,”“transcription factors,”“cell metabolism,” and “Treg cell transport and secretion mediators” , 6h:and were identified IL-23-induced pathways in Treg cells. We can see that IL23Rhi Treg showed highly inhibitory eTreg cell cha...
In addition, we attempted to investigate the in vivo efficacy of one of the best binders, MB23, in a mouse model for skin inflammation induced by intradermal injection of human IL-23 into the ear42,43. In this model, repeat dosing with human IL-23 resulted in psoriasis-like thickening ...