Regulation of IL-2–producing CD4+ T cell numbers is controlled by a quorum-sensing feedback loop as regulatory T cells sense the IL-2 produced.doi:10.1084/jem.20122759Inês F. AmadoJulien BergesR. LutherMarie-Pierre MailheS. Garcia
它参与巨噬细胞的细胞因子产生,B细胞的活化,刺激Th2细胞,同时抑制Th1细胞的细胞因子产生。 它可以形成同二聚体,与四聚体异二聚体 IL-10 受体结合,抑制 IL-1、IL-6 和 TNF 信号通路。 图片来源于文献:Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper...
responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system. IL-2分子用户评价 公司简介 百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、...
We propose that control of the IL-2p-cell numbers occurs via a quorum-sensing-like feedback loop where the produced IL-2 is sensed by both the activated CD4^+ T-cell pool and by Treg-cells, which reciprocally regulate cells of the IL-2p-cell subset. In conclusion, IL-2 acts as a ...
2014. IL-22- producing CD4 + cells are depleted in actively inflamed co- litis tissue. Mucosal Immunol 7(1):124-133.Leung J, Davenport M, Wolff M, Wiens K, Abidi W, Poles M, et al. IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue. Mucosal Immunol 2014; ...
Wang LY, Yang XY, Wu YP, et al. IL-22-producing CD3 + CD8- T cells increase in immune clearance stage of chronic HBV infection and correlate with the response of Peg-interferon treatment [J]. Clin Immunol, 2023, 250: 109320.
Human NK cells are located in the parafollicular T-cell region of lymph nodes As we hypothesized that CD56brightNK cells may interact with IL-2–producing T cells during an ongoing adaptive immune response, we examined histologically normal human lymph nodes for their presence. Normal human lymph...
[32,33,34]. Yet, a sizable population of Tregin mice is capable of producing IL-2, albeit at a lower per cell level compared to Foxp3negCD4 T cells [29]. In contrast, IL-2 expression in human peripheral blood FOXP3posCD4 T cells is limited to a subset of cells with low ...
选择性诱导Treg细胞或用体外扩增的Treg细胞进行细胞治疗已经在动物模型中得到了证明,尽管尚未在人类临床试验中取得重大成功,但它们可能为治疗人类自身免疫性疾病提供了安全有效的方法。 参考文献: 1.IL-17 and IL-17-producing cells in protection versus pathology. Nat...
Interleukin 17-producing CD4 effector Tcells develop via a lineage distinct from the T helper type 1 and 2 lineages.Nat Immunol. 2005; 6:1123–32. Z. Asadzadeh et al, The paradox of Th17 cell functions in tumor immunity, Cell Immunol. 2017 Dec;322:...