IL2RA Antibody Blocking Peptide 白介素2受体a链/IL-2RA封闭多肽 英文名称 IL2RA Antibody Blocking Peptide 中文名称 白介素 2 受体 a 链 /IL-2RA 封闭多肽 别名 Interleukin 2 receptor alpha chain; CD 25; CD
non‐IL‐2‐blocking antibodyTregstumor immune microenvironmenttumor immunotherapyCD25, also known as the interleukin‐2 receptor α chain (IL‐2Rα), is highly expressed on regulatory T cells (Tregs), but relatively lower on effector T cells (Teffs). This makes it a potential target for Treg...
Description: This AB12-3G4 monoclonal antibody reacts with and inhibits the bioactivity of human IL-2. IL-2 is a 15 kDa cytokine expressed by B cells, T cells, and dendritic cells. IL-2 signals via a heterotrimeric receptor (CD25) and results in the activation of Jak/STAT pathways. IL...
Little STAT5 phosphorylation was evident in NKG2D−/−NK cells treated with OMCP-mutIL-2 (Fig. 7e, right two columns). Next NK cell-depleted splenocytes were treated with saturating concentrations of IL-2Rα-blocking antibody (clone 3C7) prior to recombination with NK cells. IL-2Rα...
This antibody has specificity for Human IL-29. 靶标信息 IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known ...
Applications Tested: Functional Studies (Blocking).Purity: >95%. 靶标信息 IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of ...
IL-2–anti-IL-2 immune complexes Complexes of IL-2 and anti-IL-2 antibodies that exist as separate entities that are pre-complexed prior to administration or engineered as linked molecules. Depending on the anti-IL-2 antibody, IL-2 shows selectivity for the high-affinity or intermediate-affin...
Additional reported applications include (for the relevant formats) include: immunoprecipitation, blocking of IL-2 binding to CD122, and partial inhibition of IL-2 induced cell proliferation. Application References (PubMed link indicates BioLegend citation) ...
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze. Application FC - Quality tested Recommended Usage Each lot of this antibody is quality control tested byimmunofluorescent staining with flow cytometric analysis. For...
[8] Leckie MJ, ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response[J]. Lancet, 2000, 356: 2144-2148. [9] Haldar ...