InflammationImmune cellsThe present in vitro study showed that IL-2/IL-2R antibody complex facilitates Treg-induced neuroprotection in the oxygen glucose deprivation/reoxygenation (OGD/R) model of stroke. First, we examined the role of IL-2/IL-2R-treated Tregs in OGD/R-exposed rat primary ...
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain ...
IL-2 was first identified as a growth factor capable of driving the expansion of activated human T cell populations. In the more than 40 years since its discovery, a tremendous amount has been learned regarding the mechanisms that regulate the expression
Metrics Abstract The use of IL-2/JES6-1 Ab complex (IL-2 Ab Cx) has been considered as a potential therapeutic for inflammatory diseases due to its selective expansion of regulatory T cells (Tregs) in mice. Here, IL-2 Ab Cx was explored as a therapeutic agent to reduce joint inflammati...
Alteration of interleukin 2 (IL-2) pharmacokinetics and function by IL-2 antibodies induced after treatment of colorectal carcinoma patients with a combination of monoclonal antibody 17-1A, granulocyte macrophage colony-stimulating factor, and IL-2. Clin Cancer Res. 2001 May;7(5):1163-70. PMID:...
IL2 also influences memory T cell homeostasis through the regulation of memory T cell numbers and enhances major histocompatibility complex II (MHC II) expression on tumor cells. 实验方案 Product Specific Protocols WB protocol for IL-2 antibody 83558-5-RR Download protocol Standard Protocols Click ...
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain ...
Add standard and sample to the microplate that have been pre-coated with Anti-Mouse IL-2(Interleukin 2) antibody. After incubation, add Biotin-conjugated anti-Mouse IL-2(Interleukin 2) antibody. It is then combined with HRP-conjugated streptavidin to form an immune complex, then incubated and...
1976年发现的IL-2,在整个免疫治疗史上,有着不可替代的位置。Rosenberg称之为第一个人类肿瘤有效的免疫治疗方法。 IL-2/IL-2R受体里程碑研究 1976年 NCI肿瘤细胞生物学实验室的RobertGallo,使用PHA刺激淋巴细胞产生条件培养基培养骨髓细胞,其中9...
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain ...