在整个说明书和权利要求书中,所述fc区中的残基编号是免疫球蛋白重链的编号,其是根据kabat等人的sequencesofproteinsofimmunologicalinterest[免疫学目的蛋白质序列],第5版.publichealthservice[公共卫生署],nationalinstitutesofhealth[国立卫生研究院],贝塞斯达,马里兰州(1991)(通过引用明确地并入本文)中的eu索引。本文的...
所有图片(1/2) Human IgG1 Fc 货号: S0A0052 Datasheet 收藏 价格: 询价 规格: 10μg25μg50μg100μg500μg1mg 数量: 大包装询价 提交订单 产品介绍 引用文献(0) 评论(0)产品规格物种 Human 分子别名 Ig gamma-1 chain C region, Ig gamma-1 chain C region EU, Ig gamma-1 chain C ...
IgG1 Fc monomer, its preparation method, and its use. In a novel IgG1 Fc monomer sequence in which the antibody IgG1 constant region is modified, the Fc dimer is converted into an Fc monomer and the FcRn binding function is maintained by modifying the human antibody IgG1 constant region ...
与相应野生型人igg1 fc区相比,经修饰的fc区可具有增强至少约10%的对fc-γ受体(fcγr)的亲合力,优选对fcγri的亲合力。与相应野生型人igg1 fc区相比,经修饰的fc区可具有增强至少约20%、至少约30%、至少约40%、至少约50%、至少约60%、至少约70%、至少约80%、至少约90%或至少约100%的对fc-γ受体(fc...
Fc段 1. METHODS: The coding sequence of LAG-3 was amplified by polymerase chain reaction,the expression vector pcDNA-sLAG-3-Ig was constructed by inserting the PCR products of sLAG-3 and Fc sequence of IgG. 方法:将sLAG-3和Fc段基因片段克隆入pcDNA3。 2. Objective:To construct the recombin...
(IgG1κ isotype). Atezolizumab biosimilar uses the same protein sequences as the therapeutic antibody atezolizumab. Atezolizumab lacks the N-glycosylation site in its Fc region by changing an aspartic acid into alanine at amino acid position 298 (amino acid position 297 according to EU nomenclature...
A number of hIgG1 isotype control mutants(hIgG1同型对照突变体) are available. Most of the therapeutic antibody drugs carry the natural human IgG1 constant regions. There are some engineered mutants in the IgG1 Fc fragment. Changes to the IgG Fc sequence including glycosylation sites (such as...
A number of hIgG1 isotype control mutants(hIgG1同型对照突变体) are available. Most of the therapeutic antibody drugs carry the natural human IgG1 constant regions. There are some engineered mutants in the IgG1 Fc fragment. Changes to the IgG Fc sequence including glycosylation sites (such as...
描述了按照kabat和按照eu索引的氨基酸编号(两者都在kabat等,sequences of proteins of immunological interest,第5版,public health service,national institutes of health,bethesda,md.(1991)中描述)。 32.图4:多聚体(如六聚体)排布中邻近分子(分别为fc和fc’)fc之间k439/s440相互作用详细视图,显示了野生型、未...
This recombinant protein was expressed from a DNA sequence encoding the mature form of human EphrinA3 (NP_004943.1), residues 1 to 213) fused to the polyhistidine-tagged Fc region of human IgG1 at the C-terminus.Activity: This recombinant protein has not been tested.Formulation: Lyophilized ...