Disclosed is a human IgG4 Fc polypeptide variant, including a modified CH2 domain of human IgG4 Fc, wherein the modification contains a replacement of a 6-20 consecutive amino acid sequence from the N-terminus of the CH2 domain of IgG4 with a 4-18 consecutive amino acid sequence from the...
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequenc
The low affinity receptor for IgG, Fc gamma RII (CD32), has a wide distribution on hematopoietic cells where it is responsible for a diverse range of cellular responses crucial for immune regulation and resistance to infection. Fc gamma RII is a member of the immunoglobulin superfamily, containi...
(ITIM) in its own cytoplasmic domain. Fc gamma RI is a high-affinity receptor that binds monomeric IgG. Both Fc gamma RII and RIII are low-affinity receptors that bind IgG in the form of immune complexes. Two genes for human Fc gamma RIII, A and B, encoding a transmembrane receptor ...
表达区间(Protein Construction):A DNA sequence encoding the human NKG2D (NP_031386.2) (Phe78-Val216) was expressed with the Fc region of human IgG1 at the N-terminus. 存储条件(Storage): For long term storage, the product should be stored at lyophilized state at -20℃ or lower.Please avoi...
Receptors for the Fc region of IgG (Fc gamma R) are members of the Ig superfamily. Based on their genetic organization and molecular structure, three classes of human Fc gamma Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized (1 - 3). ...
Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, and FcRn receptors has been determined. ...
Human FcgRI is a 72-kDa transmembrane glycoprotein that recruits monomeric IgG1, IgG3 and IgG4—but not IgG2—with high affinity (KD B10 À 9 À 10 À 10 M). The specific exclusion of IgG2 is thought to be related to sequence determinants within the lower hinge of the Fc moiety...
The IgG1 b12 sequence was taken from its crystal structure (Protein Data Bank code 1HZH). A and B, the VL and CL domains. C–E, the VH and CH1 domains and the hinge. F and G, the CH2 and CH3 domains. H, comparison of the hinge sequences from the human IgG subclasses and ...
Additionally, it has been appreciated that the IgG Fc-receptors show significant differences in their affinity for individual antibody isotypes rendering certain isotypes more strictly regulated than others (Nimmerjahn et al., 2005). In one embodiment of the invention, FcR is a native sequence ...