Disclosed is a human IgG4 Fc polypeptide variant, including a modified CH2 domain of human IgG4 Fc, wherein the modification contains a replacement of a 6-20 consecutive amino acid sequence from the N-terminus of the CH2 domain of IgG4 with a 4-18 consecutive amino acid sequence from the...
“IgG4-hinge linker” means the hinge region between the human Fab and human IgG4 Fc (amino acid sequence: PPCPSCPAPEFLGGPS). “Llama long linker” means the hinge region between the llama Fab and llama IgG2 Fc (amino acid sequence: EPKIPQPQPKPQPQPQPQPKPQPKPEPECTCPKCP). Full size ...
No cross reactivity with human IgG1, IgG2, IgG3, IgM, IgA, IgD, IgE, mouse IgG, rat IgG, or goat IgG.Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences f...
抗原:Peptide corresponding to the Fc region of Human Ig 物种:人 宿主:兔 抗体亚型:IgG 克隆号:RM217 荧光染料:Biotin 产品介绍 技术参数 相关产品 产品介绍 类型: 二抗 同型对照: 浓度: 1 mg/mL 用法: 0.05 µg/mL-0.2 µg/mL(ELISA) ...
IgG1 and also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. The human IL-4 has a compact, globular fold, stabilised by 3 disulphide bonds. The human IL-4 shares about 40%a.a. sequence identity with mouse/rat IL-4 and they...
N-terminal Sequence Analysis Arg20 Predicted Molecular Mass 55.8 kDa (monomer) SDS-PAGE 60-70 kDa, reducing conditions Activity Measured by its binding ability in a functional ELISA.Immobilized Recombinant Human VSIG4 Fc Chimera at 5 µg/mL (100 µL/well) can bind ...
It enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. The human IL-4 has a compact, globular fold, stabilised by 3 disulphide bonds. The human IL-4 shares...
sequences (sCTLA-4) is possibly secreted (3-5). Isoforms of 56-79 aa that mainly contain parts of the cytoplasmic domain are reported. In mouse, an isoform lacking the Ig-like domain has ligand-independent inhibitory activity and is termed liCTLA-4 (6). CD28, which is structurally ...
研究级Pembrolizumab生物类似蛋白仅用于研究用途(RUO)。重组人IgG4同型对照(Recombinant human IgG4 isotype controls)是可用的。样品制备条件和最佳稀释度应由研究者通过实验确定。 人IgG1 L234A L235A P329G (LALAPG) Fc Silent突变体 多找找,一定能找到!
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequenc