17. M. Holzenberger et al., IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187 (2003). doi: 10.1038/nature01298.18. K. Young et al., Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem C...
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3Walenkamp MJ, Losekoot M, Wit JM. Molecular IGF-1 and IGF-1 receptor defects: from genetics to clinical management. Endocr Dev. 2013;24:128-37. doi: 10.1159/000342841. Epub 2013 Feb 1. PMID: 23392101. 4Racine HL, Serrat ...
胰岛素样生长因子1受体(IGF1R)检测试剂盒;IGF-I receptor检测试剂盒(ELISA方法) 本试剂盒采用夹心法酶联免疫吸附法,用于体外定量分析人血清、血浆、细胞裂解液、细胞培养上清中IGF1R的含量。 检测原理: 预先包被的抗体和检测相抗体都是亲和纯化的IGF1R多克隆抗体。检测相抗体经生物素标记。样品和生物素标记抗体先后加...
[11]11.Douglas RS, Naik V, Hwang CJ, et al. B cells from patients with Graves’ disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol 2008;181:5768-5774. [12]信达生物宣布替妥尤单抗(IGF-1R抗体)...
在 20 世纪 80 年代,它被称为“Somatomedin C.” 在地下市场上最流行的 IGF -1 类型是更持久的版本(长度更长的 氨基酸),称为长 R3 胰岛素样生长因子-I 或长 R3IGF-I。Lr3igf- 1 比地下市场上不再提供的较小氨基酸版本更有效,在这种类型 的 IGF 中,通常有两种类型(分别为 Media 和 Receptor 等级),...
Increased protease activity causes receptor dysfunction due to extracellular cleavage of different membrane receptors in hypertension. The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension. Therefore, in the prese
Antigen IGF-I receptorIn this paper, we provide an antiviral antibody, i.e. the receptor of IGF-I or its fragments or derivatives, which specifically combines with the receptor of IGF-I in vertebrates and shows the induction of cell growth in vertebrates.TAKAGI, KENICHIRO...
designated Group I, were specifically upregulated after stimulation of IGF1R-expressing cells with less significant changes in IR-expressing cells. These were exemplified by heparin-binding EGF-like growth factor (Hbegf) and ERBB receptor feedback inhibitor 1 (Errfi). Group II included five genes...
2. Douglas R S. Teprotumumab, an insulin-like growth factor-1 receptor antagonist antibody, in the treatment of active thyroid eye disease: a focus on proptosis[J]. Eye, 2019, 33(2): 183-190.https://doi.org/10.1038/s41433-018-0321-y....