B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and subset of memory B cells (namely IgGIgDCD27) that we have demonstrated is increased in ...
Inflammation Research (2022) 71:131–140 https://doi.org/10.1007/s00011-021-01525-3 ORIGINAL RESEARCH ARTICLE Inflammation Research Severity of SARS‑CoV‑2 infection is linked to double‑negative (CD27− IgD−) B cell subset numbers Rodrigo Cervantes‑Díaz1,2 ·...
Immunosenescence, i.e. the aging-associated decline of the capacity of the immune system, is characterized by several distinct changes in the number and functions of the immune cells. In the case of B cells, the total number of CD19+ B cells is lower in
Delayed acquisition of somatic hypermutations in repopulated IGD+CD27+ memory B cell receptors after rituximab treatment. Arthritis Rheum. 60: 2284-2293.Muhammad K, Roll P, Einsele H, Dorner T, Tony HP. Delayed acquisition of somatic hypermutations in repopulated IGD + CD27+ memory B cell ...
Plasmodium falciparum infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell s
浆细胞白血病(plasmacell leukemia,PCL)是一种罕见、高度侵袭的恶性浆细胞肿瘤,国外文献报道的发病率约为0.04/10万,mOS仅为4-12个月,分为原发性浆细胞白血病(pPCL)和继发性浆细胞白血病(sPCL)。pPCL发生于无多发性骨髓瘤(multiplemyeloma,MM)病史的患者,起病时外周...
[3] G A, X Q, C A, et al. Multiple myeloma patients with low proportion of circulating plasma cells had similar survival with primary plasma cell leukemia patients [J]. Annals of hematology, 2015, 94(2): 257-...
Preferential depletion of a splenic marginal zone-like peripheral blood CD27+B220- memory B cell population in HIV-1 infected individuals In addition to CD4+ T cell depletion, HIV-1 infection is characterized by changes in humoral immunity including hypergammaglobulinemia, polyclonal B cell ... ...
Flow cytometric analysis revealed substantial reduction of switched memory B cells (IgM–, IgD–, CD27+) in 9 of 10 patients, whereas numbers of naïve, IgM+ memory, transitional, and activated B cells were normal. Serum levels of IgM, IgG, IgA, and subclasses were normal. In vitro...
Alexa Fluor® 700 anti-mouse IgD Antibody - Surface IgD is an important B cell differentiation marker..