Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is ...
Double negative (IgG + IgD-CD27-) B cells are increased in a cohort of moderate-severe Alzheimer's disease patients and show a pro-inflammatory ... M Bulati,S Buffa,A Martorana,... - 《Journal of Alzhmers Disease Jad》 被引量: 0发表: 2015年 B-cell phenotype and IgD-CD27- memory...
We examined the alterations of memory CD4 + T cell subsets bearing surface receptors linked to either Th1 or Th2 cytokine production as well as natural kil... X Wu,M Osoegawa,K Yamasaki,... - 《Journal of the Neurological Sciences》 被引量: 85发表: 2000年 CD5+ B cells and CD48 T...
B cell subsets were classified as either nave (CD27—IgD+), class-switched memory (CD27+IgD—), unswitched memory (CD27+IgD+) or double negative (DN)(CD27—IgD—). DN B cells were further characterised into DN1 (CXCR5+CD21+) and DN2 (CXCR5—CD21—) subsets. In vitro co-...
Marginal zone B cells in infants express the enzyme activation induced deaminase (AID) essential for somatic hypermutation but in adults, these same cell types do not express AID [4]. The peripheral equivalent of the marginal zone cell is the IgM+IgD+CD27+CD19+ non-class switched memory B ...
Immunosenescence, i.e. the aging-associated decline of the capacity of the immune system, is characterized by several distinct changes in the number and functions of the immune cells. In the case of B cells, the total number of CD19+ B cells is lower in
The present study analyzed peripheral blood B cell populations separated by IgD and CD27 expression in six males with X-linked hyper-IgM syndrome (XHIM). Costimulation of mononuclear cells from most of the patients induced no to low levels of class switching from IgM to IgG and IgA with Stap...
Typically, the circulating B-cell pool of such patients is dominated by IgD+CD27− naive B cells. The remaining cells are immature bone marrow–derived transitional B cells (distinguished by CD10 expression and normally present in very low numbers in healthy donor blood) and a small ...
Flow cytometric analysis of peripheral blood lymphocytes revealed a reduction of class-switched CD27(+)IgM(-)IgD(-) memory B cells below 0.4% in 77% of our patients (group I), while this B-cell subpopulation exceeded 0.5% in all healthy donors and in 23% of CVID patients (group II)....
b cells before isotype switching and for cells with b cell regulatory dysfunction [ 15 , 20 ]. igd secretion may be a marker of a regulatory phenotype during any chronic infection, but is unlikely to be antigen- or disease-specific. as mentioned before, normal canine b cells co-express ...