Epitopes that induce IFNg production in human CD4+ T cells.Kerrie, VaughanJulia, PonomarenkoBjoern, PetersAlessandro, Sette
predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, 2007).[supplied by ...
IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells,which respond to IFN-gamma signaling by increasing the surface expression of class I MHC pro
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway Signal transduction via MAP kinase pathways plays a key role in a variety of cellular responses, including growth factor-induced proliferation, differentia... Rincon,M. - 《Embo Journal》 被引量:...
Naive CD4 T cells were isolated from DO11.10 mice and either assayed directly by ChIP or grown under Th1 or Th2 polarizing conditions. After 5 days of culture, ChIP was performed with either an acetylated H4 (A) or T-bet (B) antibody in resting Th1 and Th2 cells (light colored bars)...
CD4+ T cells developing toward a Th2 fate express IL-4, IL-5, and IL-13 while inhibiting production of cytokines associated with other Th types, such as the Th1 cytokine IFN- γ. IL-4-producing Th2 effector cells give rise to a long-lived memory population committed to reactivation of...
Response to anti-PD1 therapy is strongly associated with the expression of its ligand on melanoma cells and the presence of CD8 þ T cells in the margin or center of metastatic lesions5. How T cells mediate disease stabilization or regression of bulky tumour masses remained unclear so far. ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook interferon gamma (redirected fromIFNg) Also found in:Medical,Acronyms,Encyclopedia. interferon gamma n. Seegamma interferon. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016...
Na茂ve CD4 T cells can differentiate into at least two different types of T helpers, Th1 and Th2 cells. Th2 cells, capable of producing IL-4, IL-5 and IL-1... Jinfang,Zhu,Hidehiro,... - 《Cell Research》 被引量: 629发表: 2006年 Cutting edge: influence of Tmevpg1, a long in...
(b) Naive CD4 T cells were stimulated under Th1 conditions and then infected with a retrovirus vector carrying WT or mutant Gata3 cDNA. Three days later, the retrovirus-infected GFP-expressing cells were purified and the levels of mRNA of Tbx21 and Ifng were measured by RT-qPCR. The ...