IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigenmediated CD4+ T cell death[J].International Immunology,2009,(01):73-80.doi:10.1093/intimm/dxn125.Atsumi T, Sato M, Kamimura D, Moroi A, Iwakura Y, Betz UA, Yoshimura A, Nishihara M, Hirano T...
Here, we demonstrate the presence of pRL1a-recognizing CD8 + T-cells in pRL1a MAP-immunized and RL male 1-bearing BALB/c and (BALB/ cxC57BL/6)F 1 mice by using IFN ELISPOT and H-2L d /pRL1a tetramer assays. A few IFN ELISPOTs and no tetramer-positive cells were detected ex ...
CD8+ T cells and IFN-gamma participate in the spontaneous regression of the subcutaneous MOPC-104E plasmacytoma /Typescript (photocopy). Thesis (Ph. D... DG Mordue 被引量: 0发表: 0年 A Critical Requirement of Interferon ??-mediated Angiostasis for Tumor Rejection by CD8+ T Cells It is ...
Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression in the rat. Differential cytokine production by T cells plays an important role in the outcome of the immune response. We show that the level of CD45RC expression diff... E Xystrakis,P Ca...
IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells,which respond to IFN-gamma signaling by increasing the surface expression of class I MHC pro
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IFN γ is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN γ expression is induced by IL-2, TNF-α and IL-12 and suppressed by IL-4, IL-10, and TGF-β (2). IFN γ binds to IFN γ receptor (IFNGR), which stimulates ...
Our data suggested that an augmented frequency of activated CD38+CD8+ T cells as well as the presence of the A allele of IFNγ polymorphism could contribute to a reduced virological suppression in patients under antiretroviral therapy. 展开 ...
IFN-γ activates cells via a different receptor than IFN-α and IFN-β, which accounts for the different physiological properties of the proteins. Production of IFN-γ is largely restricted to activated CD4+ TH1 T cells, CD8+ T cells, and natural killer cells. One of the most important ...
When sorted CD8+ CD122+ T cells were stimulated in vitro by the anti-CD3 Ab, they promptly produced a much larger amount of IFN-gamma than did CD8+ CD122- T cells or CD4+ T cells, whereas only CD4+ T cells produced IL-4. The depletion of CD8+ CD122+ T cells from whole sple...