CD4+T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We recently identified cDC1s with a transcriptomic imprint of CD4+T-cell help, specifically in T-cell-infiltrated huma...
1a). We next investigated immune features that may drive this TP immune pattern, showing no difference in CD3+T cell frequency among the groups (Fig. 1bI). Compared with HDs, however, UPs and TPs show some decrease in CD4+T cells (Fig. 1bII), with a concomitant increase in CD8+T ...
in chronic Hepatitis B Virus (HBV) infected individuals by determining the expression of IL 4/IFN γ in single CD4 + T cell from peripheral blood, and to analyze the role of Th 1/Th 2 cytokines in chronic HBV infection Methods Peripheral blood mononuclear cells (PBMCs) were isolated from ...
CD4+ T Cells Are Required for the Development of Cytotoxic CD8+ T Cells During Mycobacterium tuberculosis Infection The control of acute and chronic Mycobacterium tuberculosis infection is dependent on CD4(+) T cells. In a variety of systems CD8(+) T cell effector respon... NV Serbina,V Laza...
Sign in CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume 1870, Issue 4,April 2024, Page 167121 Purchase options
MyD88 Signaling in CD4 T Cells Promotes IFN- Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection Hematopoietic stem and progenitor cell (HSPC) phenotype and function can change in response to infectious challenge. These changes can be mediated by cytok...
CD3+CD4+细胞分泌IL-4和IFN-γ的同时升高表明FeCocktail疫苗免疫诱导了Th1和Th2的平衡免疫反应。由于PRRSV特异性细胞毒性T淋巴细胞对病毒清除至关重要,接下来作者分析了CD3+CD8+ T细胞的活化。与单体蛋白相比,FeCocktail显著增强了抗原特异性多功能CD8+ T细胞的活化,表现为CD8+ T细胞释放IFN-γ和IL-2的比例和数量...
CD4+效应T细胞与IFNγ+CTL类似，产生IFNγ的TH1细胞在分化后降低IFNGR2的表达，提高其存活率，从而在TME中发挥抗肿瘤作用。TH1细胞通过T-bet和抑制RUNX1积极抑制向TH17细胞的极化，增强的TH1细胞基因转录程序的表达，对于肿瘤清除最有效。IFNγ通过SOCS1和T-bet来阻止向TH2的极化，它们分别抑制IL-4受体信号传导和...
IFN-γ derived from activated human CD4+ T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strainSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit both T cell ... J Shimizu,T Sasaki,GH Ong,... - 《Scientific Reports...
In conclusion, CD8+ T cells suppressed the proliferation of NSCs and promoted the differentiation of NSCs into astrocytes by the IFN-γ-STAT1-GFAP/Aldhl1l axis. Our study identifies INF-γ as a critical mediator of CD8+ T-cell-NSC cross talk and a potential node for therapeutic intervention...