STAT1 与核转录元件 GAS(gamma-activated site)结合,继而激活干扰素-γ 刺激基因(interferon-stimulated genes,ISGs)的转录,合成许多细胞因子如 CXC 趋化因子配体 10(CXC chemokine ligand 10,CXCL10)以及干扰素调节因子 (interferon regulatory factor,IRF)[6-8]。JAK1 和 STAT1 为成肌细胞的增殖所必须,并且有强大...
which makes them interesting for clinical use8,9. Although the mechanisms underlying the immunomodulatory function of MSCs are not completely understood, they appear to involve a complex network, that involves the inhibition of T-cell activation and the generation of regulatory...
These data provide important insight into the regulatory effects of IFN-γ on the biological behavior of DPSCs and indicate a promising therapeutic strategy for dentin/pulp tissue engineering in future endodontic treatment. Dental caries is a chronic infectious disease, which can lead to the ...
reported that CD4+ T cell-derived GM-CSF drives macrophage M1-like polarization in the absence of IFN-γ signaling. This IFN-γ-independent activation is nitric oxide-independent and contributes to the control of Mycobacterium tuberculosis infection. It requires the activation of transcription factor ...
Green tea polyphenols (GrTP) have been previously shown to decrease endotoxin-induced tumor necrosis factor-α production and lethality in mice. Our presen... Varilek,Gary,W.,... - 《Journal of Nutrition》 被引量: 242发表: 2001年 A novel regulatory mechanism of naringenin through inhibition ...
Zika virus (ZIKV) primarily spreads through mosquito bites and can lead to microcephaly in infants and Guillain-Barre syndrome in adults. It is noteworthy that ZIKV can persist in the semen of infected males for extended periods and can be sexually trans
For example, interferon regulatory factor-1 (IRF-1), the member of the IRF family, is highly expressed in IFN-γ stimulated cells. Its activation induces the expression of a variety of genes involved in biological processes such as cell cycle regulation, apoptosis, growth inhibition, and tumor...
Here, we report that LANA-1 inhibits IFN-β transcription and synthesis by competing with the binding of interferon regulatory factor-3 (IRF3) to the IFNB promoter. Using mutants of LANA-1, we have identified the central acidic repeated region as the domain essential for interfering with the ...
HCMV infection of human foreskin fibroblasts induced NOD2, the downstream receptor-interacting serine/threonine-protein kinase 2 (RIPK2), resulting in phosphorylation of TANK- binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3). MDP treatment following infection at low multiplicity (MOI...
In young children and immunocompromised patients, asthmatic disease is often complicated with common viral infections such as respiratory syncytial virus (RSV) [1,2,3,4,5]. While several studies have explored the causal role of a RSV infection in asthma development, wherein RSV infection occurs ...