10]. Suppression of components of the translocon-associated protein (TRAP) complex such as TRAP-β and Sec61 β have been found to impair DNA-induced type I interferon (IFN-I) signals downstream of STING [11]. The TRAP complex has been shown...
10]. Suppression of components of the translocon-associated protein (TRAP) complex such as TRAP-β and Sec61 β have been found to impair DNA-induced type I interferon (IFN-I) signals downstream of STING [11]. The TRAP complex has been shown...
Cancer immunotherapy has rapidly transformed cancer treatment, yet resistance remains a significant hurdle, limiting its efficacy in many patients. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have emerged as pivotal regulators of gene exp
For example, inflammatory bowel disease (IBD) is associated with colon cancer and an infection by Helicobacter pylori progressively leads to gastric carcinoma [3], [4]. However, despite the numerous examples of the apparent association of chronic inflammatory conditions with higher incidences of ...
The availability of AP-1 sites to Jun TFs allows TCR-driven effector programs to be modulated in a stage-specific and contextual manner in CD8 + T cells, allowing for the generation of transcriptionally intermediate memory cells [7]. Bach2 inhibits interferon regulatory Factor 4 (IRF4)-...
IRF7 phosphorylation and inhibits IFN induction [61,62]. For EBV, TLR3 was detected to be highly expressed in EBV-associated nasopharyngeal carcinomas (NPC) cell lines and clinical specimens [63]. Importantly, EBV noncoding RNA EBERs induce an inflammatory response via TLR3 in NPC cells, ...
Table 1. Summary of therapy resistance mechanisms driven by tumor microenvironment in pancreatic cancer. 5. Cancer-Associated Fibroblasts and Therapy Resistance CAFs are spindle-shaped, non-neoplastic cells located in the TME. Pancreatic fibroblasts and PSCs are considered two different cell populations...
described that TLR7 loss-of-function variants were present in 2% of young male patients thus establishingTLR7as the most important susceptibility gene for life-threatening disease46. Recently, we have described a close interaction between TLR7 expression and the IFN-I signalling pathway mediated ...
Type 1 long interspersed elements, or LINE-1, are the only retroelements that replicate autonomously in human cells. The retrotransposition process of LINE-1 can trigger the activation of the innate immune system and has been proposed to play a role in t
In the rat kidney proximal tubular cells, the knockdown of Irf8 suppressed cisplatin-induced apoptosis, supporting a pro-death role of Irf8 in renal tubular cells. Thus, DNA methylation plays a protective role in cisplatin-induced AKI by regulating specific genes, such as Irf8....