Key interferon (IFN) cell signaling pathway targets Two subtypes of IFN comprise the IFN family of cytokines: Type I IFN (IFNAR) Over 20 variants identified, including IFNα and IFNβ. All share the ability to bind to IFNAR receptors. ...
The interferon (IFN) pathway plays a critical role in the human immune response. Following viral infection, the human body triggers a complex regulatory system of innate and adaptive immune responses designed to defend against the virus. One of the many responses to the viral invasion...
Huyghe L et al. Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies. EMBO Mol Med. 2020 Feb 7;12(2):e11223. Gao J et al. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell....
Huyghe L et al. Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies. EMBO Mol Med. 2020 Feb 7;12(2):e11223. Gao J et al. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of...
[3] Gao J, Shi LZ, Zhao H, et al. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016;167(2):397-404.e9. doi:10.1016/j.cell.2016.08.069 [4] Kaplan DH, Shankaran V, Dighe AS, et al. Demonstration of an interferon gam...
Gao, J. et al. Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy. Cell 167, 397–404.e9 (2016) Benci, J. L. et al. Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune ...
Gao J et al. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016 Oct 6;167(2):397-404.e9.
The interferon-gamma (IFN-γ) signal transduction pathway closely resembles the canonical Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. The IFN-γ Pathway is thus a paradigm for most other JAK-STAT pathways that result in dimerization of STAT transcription factors...
2. Powers, R. K. et al. Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors. Nat. Commun. 10, 4766 (2019).3. Waugh, K. A. et al. Mass cytometry reveals global immune remodeling with multi-lineage hypersensitivity to type I interferon in Down syndrome....
Gao, J. et al. Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy. Cell 167, 397–404.e9 (2016) Benci, J. L. et al. Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint blockade. Cell...