Macrophage- or dendritic cell-derived interferon (IFN)-alpha/beta is a key cytokine in regulation of NK and T cell functions. We demonstrate here that in addition to activating IFN-gamma gene expression, IFN-alpha/beta and IL-12 enhance the mRNA expression of IL-21 in activated human T ...
In the RAW264.7 macrophage cell line, TNF-alpha treatment indeed recruits STAT-1alpha to the TNFR1, and this association is abrogated when cells are exposed to IFN-gamma. TNF-alpha treatment induces a more robust activation of NF-kappaB in STAT-1alpha-deficient cells, and restoration of STAT...
Klass, M. et al., (2023), "Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions synergizes with other macrophage receptors to promote phagocytosis", Glycoconjugate J., PMID: 36738392, DOI: 10.1007/s10719-022-10097-1 Zhu, J. et al., (2022), "Lin...
Dendritic cells (DC) generated after a short-term exposure of monocytes to IFN-alpha and GM-CSF (IFN-DC) are highly effective in inducing cross-priming of CD8(+ )T cells against viral antigens. We have investigated the mechanisms responsible for the special attitude of these DC and compared...
Klass, M. et al., (2023), "Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions synergizes with other macrophage receptors to promote phagocytosis", Glycoconjugate J., PMID: 36738392, DOI: 10.1007/s10719-022-10097-1...
Interferon alpha (IFN)-Macrophage Interactions in Human Immunodeficiency Virus (HIV) Infection: Role of IFN in the Tempo and Progression of HIV Disease Components of the host immune response that constrain virus replication and affect long-lasting antiviral immunity following HIV infection are incompletel...
Hu X, Chakravarty SD, Ivashkiv LB (2008) Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol Rev 226:41–56. doi:10.1111/j.1600-065X.2008.00707.x CrossRef Kagitani-Shimono K, Mohri I, Oda ...
First, both IFN-γ and TNF-α significantly reduced the bacterial growth in macrophages, indicating that these cytokines participate in up-regulation of macrophage anti-MAIC function. Second, although MAIC-infected macrophages produced substantial amounts of IL-10 and TGF-β, neutralization of ...
The macrophage cytokine IL-1beta in combination with IFN-gamma and TNF-alpha, plays an important role for beta-cell dysfunction and death. Signal ... D. L. and Eizirik,T Mandrup-Poulsen - 《Diabetologia》 被引量: 1514发表: 2002年 Cloning of the human gene for intercellular adhesion molec...
Klass, M. et al., (2023), "Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions synergizes with other macrophage receptors to promote phagocytosis", Glycoconjugate J., PMID: 36738392, DOI: 10.1007/s10719-022-10097-1 ...