在许多类型的细胞中,IFN-γ诱导细胞因子在生产和 上调多种膜蛋白的表达,包括 I 型和 II 型主要组织相容性复合体(MHC)抗原、Fc 受体、白细胞黏附分子和 B7 家族抗原。IFN-γ是强大的巨噬细胞效应激活剂;它指导 B 细胞免疫球蛋白的合成、类型转变及分泌。IFN-γ通过抑制 Th2 细胞的分化和刺激...
MHC class II expression was restricted to enterocytes of IFN-gamma-treated SCID and BALB/c mice, present at basolateral membranes and within endosomal compartments. These enterocytes further revealed colocalization of class II antigens and OVA in endosomes. We suggest that antigen trafficking into ...
IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with ot...
IFN-gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-gamma receptors are present in most immune cells,which respond to IFN-gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of...
干扰素-γ是一种有效的多功能细胞因子,主要由活化的NK细胞和T细胞释放。IFN-γ的主要特征在于其抗病毒活性,然后被证明具有多种功能,例如抗增殖、免疫调节和促炎活性。IFN-γ可通过抗原呈递细胞上调MHC I类和II类抗原的表达。 序列 MHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLIT...
干扰素γ在激活对病毒和肿瘤的先天性和适应性免疫反应方面具有更广泛的作用,部分是通过上调参与细胞周期调节、凋亡和抗原加工/呈递的基因的转录。尽管如此,啮齿动物和人类滋养层细胞对IFNG的反应减弱,这反映了这些细胞对IFNG介导的主要组织相容性复合体(MHC)II类移植抗原表达的激活的抵抗力。
upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required fo...
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IFN-γ markedly induced expression of MHC-I instantly, while its effects on MHC-II were less dramatic and delayed up to 4 days. This is due to a slower intracellular transport of the MHC-II antigen to the membrane surface. More important is that MSCs showed a reduction in their ...
IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antige...