Jin et al., "IDH1 and IDH2 mutations in gliomas," The New England Journal of Medicine, vol. 360, no. 8, pp. 765-773, 2009.Cohen AL, Holmen SL, Colman H. 2013. IDH1 and IDH2 mutations in gliomas. Curr Neurol Neurosci Rep. 13(5):345....
2. Yan, H. et al. IDH1 and IDH2 mutations in gliomas. The New England journal of medicine360, 765-773, doi:10.1056/NEJMoa0808710 (2009).3. Waitkus, M. S., Diplas, B. H. & Yan, H. Biological Role and Therapeutic Potential of IDH Mutations in Cancer. Cancer cell 34, 186-195...
IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009; 360: 765–773. 24 Bleeker FE, Lamba S, Leenstra S, Troost D, Hulsebos T, Vandertop WP et al. IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum Mutat ...
2. Yan, H. et al. IDH1 and IDH2 mutations in gliomas.The New England journal of medicine360, 765-773, doi:10.1056/NEJMoa0808710 (2009). 3. Waitkus, M. S., Diplas, B. H. & Yan, H. Biological Role and Therapeutic Poten...
A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (sec...
2. Yan, H. et al. IDH1 and IDH2 mutations in gliomas.The New England journal of medicine360, 765-773, doi:10.1056/NEJMoa0808710 (2009). 3. Waitkus, M. S., Diplas, B. H. & Yan, H. Biological Role and Therapeutic Potential of IDH Mutations in Cancer.Cancer cell34, 186-195, do...
Mutations were also found in 40% of solitary central cartilaginous tumors and in four chondrosarcoma cell lines, which will enable functional studies to assess the role of IDH1 and IDH2 mutations in tumor formation.This is a preview of subscription content, access via your institution ...
[6]Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med.2009;360(8):765-773. [7][4] Hartmann C, Meyer J, Balss J, et al. Type and frequency of IDH1 and IDH2 mutations ...
[7][4] Hartmann C, Meyer J, Balss J, et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 2009;118(4):469-474. ...
Change of codon and amino acid residue in 胶质瘤IDH1/2 基因突变的研究进展简要概述。 different IDH1/2 mutationsingliomas 一、 基因生理功能及其在胶质瘤中的突 Mutationtype Changeofcodon* Changeofaminoacid IDH1/2 变类型 IDH1 R132H A 1.生理功能 IDH1/2 基因为IDH 基因家族成 CGT➝C T Arginine...