The systematic sequencing of glioblastoma multiforme (GBM) genomes has identified the recurrent mutation of IDH1, a gene encoding NADP +-dependent isocitrate dehydrogenase 1 (IDH1) that catalyzes the oxidative decarboxylation of isocitrate yielding 伪-ketoglutarate (伪-KG). Subsequent studies have ...
IDH2\\r mutation in gliomas including novel mutation]]>astrocytomaglioblastomaIDH1IDH2oligodendrogliomaGlioblastomas (GBMs) are the most aggressive type of primary brain tumors and provide a dismal prognosis. Thus far, several key genes have been identified in GBMs as prognostic and therapeutic ...
教授在论文《IDH-Mutation Is a Weak Predictor of LongTerm Survival in Glioblastoma Patients》中通过一个大型的连续单中心系列回顾性研究,比较长期存活者(定义为>生存3年)的IDH突变率和非长期存活者的IDH突变率,来阐明以上争议。 到目前为止,尽管在治疗模式上有所改善,包括手术、放疗和化疗,但胶质母细胞瘤患者的...
High-grade gliomas (HGG), on the other hand, consist of astrocytomas with an IDH mutation, designated as grade 3 and 4, as well as glioblastomas (GBM) with an IDH-wildtype status, which are grade 4 malignancies [2]. LGG patients will progress to HGG without effective treatment [3]. ...
神外前沿-协和神经肿瘤周刊讯,2019年8月,Cancers杂志(IF=6.162)发表了来自意大利维罗纳大学Valeria Barresi教授团队的一篇临床研究。题为Ultra-Mutationin IDH Wild-Type Glioblastomas of Patients Younger than 55 Years is Associatedwith Defective Mismatch Repair, Microsatellite Instability, and Giant CellEnrichment ...
et al. A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model. Mol. Cancer Ther. 19, 375–383 (2020). Article CAS PubMed Google Scholar Okoye-Okafor, U. C. et al. New IDH1 ...
10. Wang P, Dong Q, Zhang C, Kuan PF, Liu Y, Jeck WR, et al. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2013) 32(25):3091–100.11. Rizzato M, Brignola S, Munari G, ...
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation Mutations in isocitrate dehydrogenase (IDH) 1 are high-frequency events in low grade glioma and secondary glioblastoma and IDH1 mutant glioma are vulnerabl... L Zhou,Z Wang,C Hu,... -...
2. FDA approves vorasidenib for grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation. News release. FDA. August 6, 2024. Accessed October 21, 2024. https://tinyurl.com/3jv48wa9Recent Videos Unveiling the Potential of Combined Therapies for Glioblastoma Understanding ...
9. Ma B, Meng H, Tian Y, Wang Y, Song T, Zhang T, et al. Distinct clinical and prognostic implication of IDH1/2 mutation and other most frequent mutations in large duct and small duct subtypes of intrahepatic cholangiocarcinoma. BMC Cancer (2020) 20:318. ...