Glioblastomas (GBMs) are the most aggressive type of primary brain tumors and provide a dismal prognosis. Thus far, several key genes have been identified in GBMs as prognostic and therapeutic targets. Mutations in two isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, commonly occur in low...
High-grade gliomas (HGG), on the other hand, consist of astrocytomas with an IDH mutation, designated as grade 3 and 4, as well as glioblastomas (GBM) with an IDH-wildtype status, which are grade 4 malignancies [2]. LGG patients will progress to HGG without effective treatment [3]. ...
Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data GaRyoung Lee Sang Mi Lee Hyun Uk Kim Genome Biology (2024) Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression Fatima Khan Yiyun...
Diffuse glioma — rare homozygous IDH point mutation, is it an oncogenetic mechanism? Neuropathology 37, 582–585 (2017). Article CAS PubMed Google Scholar Stancheva, G. et al. IDH1/IDH2 but Not TP53 mutations predict prognosis in bulgarian glioblastoma patients. Bio. Med. Res. Int. 2014...
For this purpose, we analyzed protein expression in tissue microarrays of tumor samples stratified by patient age and IDH mutation status. We initially screened 86 unselected high-grade astrocytomas, followed by 174 IDH1- R132H1 immunonegative glioblastomas derived from patients aged 60 years and ...
Vebreltinib for Advanced Non–Small Cell Lung Cancer Harboring c-Met Exon 14 Skipping Mutation: A Multicenter, Single-Arm, Phase II KUNPENG Study Article 作者:Wang, Zhe-Hai;Yao, Yu;Hu, Jie;Cheng, Ying;Zhang, Wei;Yang, Jin-Ji;Chen, Yuan;Shi, He-Peng;Xue, Wei-Zhe;Wu, Lin;Chen, Ji...
Histopathologically, there were 63 (72.4%) glioblastomas, 16 (18.4%) anaplastic astrocytomas, six (6.9%) diffuse astrocytomas, and one (1.1%) each of anaplastic oligodendrocytoma, and anaplastic oligodendroglioma. Common molecular genetic changes in IDH-wt gliomas included TERT promoter mutation ...
IDH-wildtype glioblastoma (GBM) is the most common primary brain malignancy in adults [1]. The prognosis is poor, and the treatment paradigm—a combination of surgical resection, radiotherapy and alkylating chemotherapy—has remained largely unchanged for the past two decades [2]. Advances in tumo...
Of those, approximately 20% harbor an IDH mutation, including 100% of grade 2 and grade 3 adult-type diffuse gliomas, as well as a much smaller portion of the grade 4 tumors.1,2 Establishing the IDH mutation status of these tumors is essential to b...
MLK3 Is Associated With Poor Prognosis in Patients With Glioblastomas and Actin Cytoskeleton Remodeling in Glioblastoma Cells Mixed lineage kinase 3 (MLK3) has been implicated in human melanoma and breast cancers. However, the clinical significance of MLK3 in human gliomas and the... Y Zhu,JM Sun...