Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout
Subsequently, to ascertain the potential role of hepatic iron as a key contributor to the development of MASH, we investigated the liver function and pathology in mice subjected to a high-iron diet (HID). In accordance with the augmented positive area of Perls’ Blue staining observed in mice...
Currently, it is believed that IPF develops as a result of the interactions between complex intracellular signaling cascades and multiple cell types, including immune cells, epithelial cells, and fibroblasts, bringing forth the importance of cell heterogeneity [3]. Two approved drugs for the treatment...
This model would serve as an unbiased assessment of the antibodies but in doing so may not necessarily retain a strong impetus to optimize protocols. A combination of the two models also represents a viable option, depending on the application. The ultimate choice of an operational validation ...
Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer and the leading cause of cancer-related mortality. Identifying effective drug targets is crucial for advancing LUAD treatment strategies. This study employed proteome-wide
KILR is a sense intronic lncRNA transcribed from the KCTD1-5 promoter The two most significant crRNAs targeting KILR were individually validated, confirming that both crRNAs can knock down KILR (Fig. 1c) and increased the proliferation of MCF7 cells (Fig. 1d). We used 5’ and 3’ ran...
Metastasis, the leading cause of cancer-related death in patients diagnosed with ovarian cancer (OC), is a complex process that involves multiple biological effects. With the continuous development of sequencing technology, single-cell sequence has emerg
Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (l
We further illustrate the immune molecule-related functions in CD. This work reveals the key role of different immune molecules in the occurrence and development of CD. Materials and methods Search strategy for CD microarray datasets A total of 73 datasets were collected from the Gene Expression ...
In this study, first, we explored the host transcriptome responses upon SARS-CoV-2 infection with those of the two previous outbreak-related pathogenic coronaviruses, SARS-CoV, and MERS-CoV, through conducting a meta-analysis at different time points. The main rationale behind this meta-analysis...