This Review discusses the major advances and changes made over the past 3 years to our understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the field has gained insight into how various molecular modules of the CAR in
To date, there have not been great breakthroughs in immunotherapy for HER2 positive breast cancer (HPBC). This study aimed to build a risk model that might contribute to predicting prognosis and discriminating the immune landscape in patients with HPBC.
Diabetic kidney disease (DKD), has become the main cause of end-stage renal disease (ESRD) worldwide. Lately, it has been shown that the onset and advancement of DKD are linked to imbalances of gut microbiota and the abnormal generation of microbial meta
Noteworthily, increasing reports indicate that the influence of the Trp pathway exceeds the traditional focus on its metabolite 5-HT, and two other key branches of Trp, the kynurenine pathway (KP) and the indole pathway (IP), are involved in neuroendocrine activities [8, 9]. A growing body ...
Key resources table REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Rabbit polyclonal anti-CCNL2 (Cyclin L2) Novus Biologicals Cat# NB100-87009; RRID: AB_1201144 Rabbit polyclonal anti-OXSR1 (OSR1) Cell Signaling Technology Cat #3729; RRID: AB_2157610 Rabbit polyclonal anti-STK39 (SPAK) Cell Sig...
The functions of lncRNA CASC8 in normal tissues and developmental growth remain unclear, and current research primarily focuses on its regulatory role in tumor progression, its potential as a biomarker, and its candidacy as a therapeutic target. Several studies indicate that CASC8 can influence the...
Integrin is a cell-matrix adhesion molecule that not only provides mechanical engagement of the cell to the extracellular matrix but also transduces signals related to cancer and malignant tumors. Integrins have two primary functions: mechanically linking cells to the extracellular matrix (ECM) and ini...
Numerous studies have demonstrated that microgravity dramatically affects the physiological functions of human body inducing impairments in cardiovascular, musculoskeletal, endocrine and immune systems[1]. Besides, it was also suggested that cerebral malfunction occurred during or after spaceflight. For example...
However, administration of mAbs carries the risk of immune reactions such as acute anaphylaxis, serum sickness and the generation of antibodies. In addition, there are numerous adverse effects of mAbs that are related to their specific targets, including infections and cancer, autoimmune disease, and...
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in three