Reagan W. Ching2, Rachel Cotton1, Ren Li1 & David P. Bazett-Jones1 Gene loci make specific associations with compartments of the nucleus (e.g. the nuclear envelope, nucleolus, and transcription factories) and this association may determine or reflect a mechanism of genetic contro...
FCGR3A, commonly found on NK cells and nonclassical monocytes, was identified as a strong positive marker of CD8T-8 cells in smokers (log2FC = 1.63, p = 1.17 × 10−171) and nonsmokers (log2FC = 1.72, p = 5.17 × 10−119; Figure 1D; Table S3). We reanalyzed the gene ...
Table 1: Number and percentage of putative hormone-related genes spotted on the μPEACH1.0 microarray. Table 2: Number of genes representing putative common targets of different pairs of hormones as assessed in Arabidopsis [13]. The total number of hormone-related genes is given in bold on the...
Syringa pinnatifolia Hemsl. is a shrub belonging to the Oleaceae family. The peeled woody stems and roots of S. pinnatifolia are used in Chinese traditional medicine. This plant has been used for centuries, and modern pharmacological research has reveale
Supplementary Table 6 Original Data File Checklist Author Contribution Form Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archivin...
Syringa pinnatifolia Hemsl. is a shrub belonging to the Oleaceae family. The peeled woody stems and roots of S. pinnatifolia are used in Chinese traditional medicine. This plant has been used for centuries, and modern pharmacological research has reveale
Some results of the preprocessing phase is shown in Additional file 2: Table S3 of Supplement J.I, illustrating the number of reactions excluded from the search space before the main exploration procedure and before obtaining the removable reactions. The size of the search space is drastically red...
Additional file 11: Table S10 shows the sequences for all sgRNAs used. Cell viability was assessed using the CellTiter-Glo-3D cell viability assay (Promega). Briefly, EGFRvIII-GBM cells were plated in a 24-well opaque-walled plate, with 2500 cells per well. CellTiter-Glo-3D reagent was ...
1) and higher expression for 28 genes (e.g. RCCD1, ATG10, ELL, and TLR1) (summarized in Table 1 and Supplementary Data 6). For the remaining six genes (ADCY3, AMFR, APOBEC3B, CCDC127, HSPA4, and MRPS18C), conflicting directional effects were observed across different tissues, and...
(discovery) phases of drug research, a secondary pharmacology screen, performed when drug candidates reach the translational phase (e.g., preclinical safety), is required to cover a broad array of target classes, and ideally the off-target proteins should have implication(s) to human safety6. ...