Testa, B., and Mayer, J. M. (2003) The hydrolysis of amides. In Hydrolysis in Drug and Prodrug Metabolism (Chemistry, Biochemistry, and Enzymology) (Testa, B., and Mayer, J. M., Eds.) Chapter 4, pp 81-162, VHCA, Zurich.
Introduction Enantioselective Hydrolysis of Carboxylic Acid Amides Enantioselective Hydrolysis of Cyclic Amides Enantioselective Hydrolysis of Amino Acid Amides Enantioselective Hydrolysis of Hydroxy Acid Amides Enantioselective Hydrolysis of Azido Acid Amides Selective Cleavage of a C-Terminal Amide Bond Summary an...
1) hydrolysis of the amide 酰胺水解 1. 3-Chlorocephalosporin (7-amino-3-chloro-3-cephem-4-carboxylic acid,7-ACCA) as the advanced intermediate of cefaclor was synthesized in high yield started with diphenylmethyl ester of 3-hydroxy-7-phenylaceto-3-cephem-4-carboxylic acid through three-...
HYDROLYSIS OF AMIDE GROUP
Enthalpies and entropies of activation have been derived from rate constants measured over a range of temperature for the dilute acid hydrolysis of isobutyramide, diethylacetamide, α-methylbutyramide, cyclohexaneoarboxamide, cyclopentane-carboxamide, and trimethylacetamide. These data, in combination wit...
Introduction Enantioselective Hydrolysis of Carboxylic Acid Amides Enantioselective Hydrolysis of Cyclic Amides Enantioselective Hydrolysis of Amino Acid Amides Enantioselective Hydrolysis of Hydroxy Acid Amides Enantioselective Hydrolysis of Azido Acid Amides Selective Cleavage of a C-Terminal Amide Bond Summary an...
The release of aromatic amines from drugs and other xenobiotics resulting from the hydrolysis of metabolically labile amide bonds presents a safety risk through several mechanisms, including geno-, hepato- and nephrotoxicity. Whilst multiple in vitro sys
the positioning of the geminal dimethyl group adjacent to the amide functionality. lubrizol.com lubrizol.com 原子空间排列产生的抗水解性是由于在偕二甲基组中接近酰胺功能性的位置排列决定的。 cn.lubrizol.com cn.lubrizol.com [...] seals, with excellent low-temperature flex ...
Suggs et al., " Facile Hydrolysis and Formation of Amide Bonds by N-Hydroxyethylation of α-Amino Acids ", Tetrahedron Letters, 38(13):2227-2230(1997).Suggs J W,Pires R M.Facile hydrolysis and formation of amide bonds by N-hydroxyethylation of a-amino acids.. Tetrahedron Letters . 1997...
Process for the enzymatic hydrolysis of a D-α-amino-acid amide to the corresponding D-α-amino-acid, wherein an aqueous solution of the D-α-amino-acid amide is contacted with an aminoacylamidase-containing preparation obtained from a culture of Rhodococcus erythropolis or a mutant thereof and...