In the current study, we investigated the use of Trx-SARA in primary human corneal fibroblasts (HCF) to discern the relationship between the Smad pathway and the activation of a known TGFβ-target protein, thrombospondin-1 (TSP-1), and HCF proliferation. Methods:Retroviruses (RTV) were made ...
The discovery of TSPyV using rolling-circle amplification to identify a virus that had been detected by electron microscopy. Article CAS PubMed PubMed Central Google Scholar Feng, H., Shuda, M., Chang, Y. & Moore, P. S. Clonal integration of a polyomavirus in human Merkel cell ...
The c-terminal thrombospondin motif (TSP-1) of aggrecanase- 1 binds with glycosaminoglycans of aggrecan and is critical for substrate recognition and cleavage [10]. ADAMTS-4- generated products are found in the cartilage and synovial fluid Biochimica et Biophysica Acta 1773 (2007) 309–320 .else...
APCs, antigen-presenting cells; α-MSH, α-melanocyte stimulating hormone; CGRP, calcitonin gene-related peptide; Conv T cells, conventional T cells; TGF-β, transforming growth factor β; TSP-1, thrombospondin 1; VIP, vasoactive intestinal peptide. Retinoic acid is an active metabolite of ...
(aa 126-182), a 40 aa TSP type I domain (aa 220-259) and a 75 aa, C-terminal cysteine knot motif (aa 273-347). The VWC module is associated with protein-protein interaction, the TSP domain binds sulfated glycoconjugates, and the cysteine knot mediates dimerization and receptor binding ...
Angiotensin II also directly increases p38 and JNK MAPKs signaling to increase thrombospondin-1 (TSP-1) expression, which cleaves the LAP domain of TGF-β1 and converts TGF-β1 into its active form [149]. Furthermore, Angiotensin II promotes aldosterone secretion, which also increases TGF-β...
Besides glycosylation, O-fucosylation (O-linked fucose modification) has been recently identified in the TSP domain 3 of CCN2 protein [38]. Overall, these PTMs could be exploited to modulate CCN4 function; yet the PTM analysis in CCN family remains in its infancy, and more research is ...
Fig. 2: Plasma protein abundance across heart failure stages. Box plots depicting distribution of (a) CRP, (b) CXCL13, (c) Nt-proBNP, (d) PRKACA, (e) Protein C, and (f) TSP2 across cohorts representing different stages of heart failure. In addition to association with incident heart ...
Schematic diagrams of the overall gene (a) and protein domain organization (b) showing the secretory signal and the homologous domains (IGFBP insulin-like growth factor binding protein, VWC von Willebrand factor type C repeat, TSP-1 thrombospondin type 1 repeat, CT carboxy-terminal domain). The...
This analysis is based on the differential expression of genes between these two subsets that are then associated with a particular signaling pathway for which the corresponding receptors are expressed on the TSP2 population (Figure 7G). As anticipated, the Notch signaling pathway was mainly active ...