The regulatory (Treg) and Th17 subsets of T cells play opposing roles in suppressing immune response versus inducing inflammation, respectively. Th17 cells secrete proinflammatory cytokine IL-17 and protect the host against bacterial or fungal infections especially at the mucosal tissues. However, Th17...
Cytokine regulation of human Th17 differentiationBackground Th17 cells have a central role in inflammation via their pro-inflammatory cytokine production, such as interleukin (IL)-17A, -17F, -21, -22, tumor necrosis factor-伪 and the expression of master regulator transcription factor RORc. The ...
CellXVivo Human Th17 Cell Differentiation Kit (1 KT) Basic information More.. Product Name: CellXVivo Human Th17 Cell Differentiation Kit (1 KT) Synonyms: CellXVivo Human Th17 Cell Differentiation Kit (1 KT) CAS: MF: MW: 0 EINECS: Mol File: Mol File Information Error Report Your ...
Sitagliptin inhibit human lymphocytes proliferation and Thl/Th17 differentiation in vitro 喜欢 0 阅读量: 9 作者:Pinheiro,Marcelo,Maia,Okuyama,Cristina,Eunice,Gorjao,Renata,Silva,Pereira 摘要: Dipeptidyl peptidase-4 (DPP-4) inhibitors are a ne 年份: 2017 ...
While several advanced methods exist for differential expression analysis of RNA-seq data, proper tools to anal.yze RNA-seq time-course have not been proposed.Results: In this study, we use RNA-seq to measure gene expression during the early human T helper 17 (Th17) cell differentiation and ...
www.nature.com/scientificreports OPEN received: 01 July 2015 accepted: 16 September 2015 Published: 12 October 2015 Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human Qingfeng Chen1,*, Weijian Ye2,3,*, Wei Jian Tan2, Kylie Su Mei Yong1, Min Liu...
Background Both regulatory T cells (Tregs) and T helper IL-17-producing cells (Th17 cells) have been found to be involved in human malignancies, however, the possible implication of Tregs in regulating generation and differentiation of Th17 cells in malignant pleural effusion remains to be elucida...
Th17-cell differentiation, Th1 and Th2 cell differentiation and the TNF signaling pathway25,29(Supplementary Fig.13d). High expression of genes in apoptosis-related pathways also indicated that more DP cells in type 2 TETs were undergoing positive selection (Supplementary Fig.13d). Compared with ...
More recently, the mechanisms by which IL-2 regulates CD4+ T cell differentiation and function have been elucidated. IL-2 also regulates the effector and memory responses of CD8+ T cells, and the loss of IL-2 or responsiveness to IL-2 at least in part explains the exhausted phenotype that...
On this basis, via COX2-dependent PGE2 secretion, fibroblast-like cells can polarize macrophages to an alternative anti-inflammatory M2 phenotype, attenuate T cell proliferation and differentiation to Th17, and increase T cell differentiation to Tregs (reviewed in [60]). In parallel, a pioneering ...