Studies have shown that tumor growth of triple negative breast cancer (TNBC) CDX as well as TNBC and non-small cell lung cancer (NSCLC) PDX – after being transplanted into HIS mice and treated with another anti-PD-1 antibody, Pembrolizumab (Keytruda) – was significantly delayed, mirroring ...
PBMCs of Monkey-#5 post-transplant (8 wpt) alone (Null) or incubated with CD3 antibody were applied as negative and positive control. h, Number of spots (left) detected in IFN-γ ELISpot assay and cytokine activity (right) of various incubation conditions as quantified by ELISpot reader ...
Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment1,2. However, this therapeutic strategy has not been systematically assessed in large animal models physiologically similar to humans, such as no
PBMC or isolated T- or NK-cell preparations were used to humanize mice by single or multiple i.v. injections. CDX and PDX from different entities were s.c. (i.e. lymphoma) and/or i.v. (leukemia) transplanted on those humanized mice. Tumor growth of orthotopic models was followed up ...
Thus, further analysis is required to establish CDX2+ human TE-like stem cells. We cultured nCTs in suspension (Turco et al., 2018). The morphology of nCT-derived organoids (nCT organoids) was similar to that of trophoblast organoids derived from placenta (Figure S4A). nCT organoids were...
Human challenge model HIV: Human immunodeficiency virus HLA: Human leukocyte antigen HSC: Hematopoietic stem cell Ig: Immunoglobulin KI: Knock-in MHC: Major histocompatibility complex NHP: Nonhuman primate PBMC: Peripheral blood mononuclear cell
Notch-1 and CDX2 mRNA expression was significantly decreased in the Notch-1 siRNA-treated mice (P ¼ 0.001 and 0.007), but Hes-1 and Atoh-1 expressions were unchanged (Supplementary Figure S1B). Epithelial prolifera- tion, apoptosis, and goblet cell loss did not show any differences ...
(iPSC-TB); H9 hESC line; H1, ME, NPC, TBL, MSC, adipose-derived stem (ADS) cells; IMR90, ADS-derived adipocytes; foreskin fibroblasts (FF); the colon tissue (Berman et al., 2012); peripheral blood mononuclear cells (PBMC) (Li et al., 2010); and sperm (Hammoud et al., 2009)...
1b). The PBMC-iPSCs also passed the PluriTest assay with high pluripotency and low novelty scores (Supplementary Fig. 1c) and maintained normal cytogenetic status (Supplementary Fig. 1d). OriP/EBNA1 vectors replicate just once per cell cycle, and in the absence of drug selection, the ...
which might be responsible for the changes in OXPHOS and RP gene expression. IFN-γ production in NK cells was previously proposed as an EP2/EP4-dependent switch from protumor to antitumor inflammatory phenotype in the early phase of tumor growth in the COX-dependent tumor model17,38. We ther...