Highly permissive to human xenograft, including primary or established tumor cells (CDX or PDXs) by virtue of the SIRPαNODallele expression Lifespan after humanization similar to that of the wild-type mouse⇨supports long-term engraftment studies ...
PBMC or isolated T- or NK-cell preparations were used to humanize mice by single or multiple i.v. injections. CDX and PDX from different entities were s.c. (i.e. lymphoma) and/or i.v. (leukemia) transplanted on those humanized mice. Tumor growth of orthotopic models was followed up ...
PBMCs of Monkey-#5 post-transplant (8 wpt) alone (Null) or incubated with CD3 antibody were applied as negative and positive control. h, Number of spots (left) detected in IFN-γ ELISpot assay and cytokine activity (right) of various incubation conditions as quantified by ELISpot reader ...
Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment1,2. However, this therapeutic strategy has not been systematically assessed in large animal models physiologically similar to humans, such as no
S2B). Furthermore, the microfluidic culture seemed to increase the general differentiation state of IEC at the expense of proliferation as noted by the upregulation of expression of transcription factors involved in differentiation programs HES1, CDX2 and KLF4 and a decrease of expression of stem ...
Thus, further analysis is required to establish CDX2+ human TE-like stem cells. We cultured nCTs in suspension (Turco et al., 2018). The morphology of nCT-derived organoids (nCT organoids) was similar to that of trophoblast organoids derived from placenta (Figure S4A). nCT organoids were...
Human challenge model HIV: Human immunodeficiency virus HLA: Human leukocyte antigen HSC: Hematopoietic stem cell Ig: Immunoglobulin KI: Knock-in MHC: Major histocompatibility complex NHP: Nonhuman primate PBMC: Peripheral blood mononuclear cell
(iPSC-TB); H9 hESC line; H1, ME, NPC, TBL, MSC, adipose-derived stem (ADS) cells; IMR90, ADS-derived adipocytes; foreskin fibroblasts (FF); the colon tissue (Berman et al., 2012); peripheral blood mononuclear cells (PBMC) (Li et al., 2010); and sperm (Hammoud et al., 2009)...
Personalized therapy is treatments performed for each patient and using a personalized disease model with similar characteristics to the primary tumor will undoubtedly give a more accurate prediction of the patient’s response to a given treatment.161,319,320Patient-derived organoids retain donor-specifi...
Directed biomechanical compressive forces enhance fusion efficiency in model placental trophoblast cultures Prabu Karthick Parameshwar Chen Li Christopher Moraes Scientific Reports (2024) KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2 Shil...