The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RN...
we addressed this limitation by describing the developmental trajectories of different cell types that make up the human liver at single-cell resolution. These transcriptomic analyses revealed that sequential cell-to-cell interactions direct functional maturation of hepatocytes, with non-parenchymal cells pl...
We hypothesized that there are HCC-associated cell-types that impact patient survival. Methods:We combined liver single nucleus (snRNA-seq), single cell (scRNA-seq), and bulk RNA-sequencing (RNA-seq) data to search for cell-type differences in HCC. To first identify cell-types in HCC, ...
The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RN...
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations Sonya A. MacParland, Jeff C. Liu, Xue-Zhong Ma, Brendan T. Innes, Agata M. Bartczak, Blair K. Gage, Justin Manuel, Nicholas Khuu, Juan Echeverri, Ivan Linares, Rahul Gupta, Michael L. Cheng,...
Liver cancer arises from the evolutionary selection of the dynamic tumor microenvironment (TME), in which the tumor cell generally becomes more heterogeneous; however, the mechanisms of TME-mediated transcriptional diversity of liver cancer remain unclear. Here, we assess transcriptional diversity in 15...
24. We integrated adult and fetal human hearts at a single-cell resolution, which allowed us to compare the epicardium in both stages. We approached our dataset from multiple angles and triangulated the epicardium in both adult and fetal cells using prior knowledge and unbiased clustering of ...
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喜讯:南方医科大学使用IPHASE产品在...近日,南方医科大学陈鹏组李冬平老师,使用IPHASE品牌产品:Human liver microsome、 Mouse liver microsome在Cell host & microbe(IF=30.3)权威期刊上发表题为Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism的研究型论文,揭示了口服镁...
For instance, CLEC4G/M is a potential candidate for mediating SARS-CoV infection of sinusoidal cells of the liver (Xu et al., 2020b). We found that specific cell types of the placenta, testis, intestine, and kidney co-express ACE2, ANPEP, and DPP4, and therefore seem permissive for ...