Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development | Physiological Reviews 以下为全文翻译(水平有限,仅供参考): 摘要: 体细胞核移植的发现证明,体细胞可以携带与受精卵相同的遗传密码,激活该密码的部分足以将细胞重新编程到早期发育状态。近半个世纪后,诱导多能干细胞 (iPSC...
Human induced pluripotent stem cells (iPSCs) have emerged as an invaluable resource for basic research, disease modeling, and drug discovery over recent years. Given the numerous advantages of iPSCs over alternative models—including their human origin, their ability to be differentiated into almost ...
Human iPSCs were induced to differentiate into MSCs following a clinically compliant protocol. The iPSC-MSC treatment promoted mucosal healing in colitic mice, accompanied by increased epithelial cell proliferation, CD44-positive cells, and Lgr5-positive cells. TSG-6 knockdown in iPSC-MSCs or ...
The development of human induced pluripotent stem cell (iPSC) models has greatly enhanced our ability to model disease in human cells. Methods have recently been improved, including increasing reprogramming efficiency, introducing non-viral and non-integrating methods of cell reprogramming, and using ...
Human-induced pluripotent stem cells (hiPSCs) are stem cells derived from the de-differentiation of mature somatic cells. hiPSCs are of particular interest in plastic surgery as they have the capacity to be re-differentiated into more mature cells, and cultured to grow tissues. This revie...
Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from fibroblasts of six unrelated CDD patients鈥攖hree males and three females. These patients are clinically diagnosed to present with classic CDD phenotypes, including refractory epilepsy and global ...
Human induced pluripotent stem cells (iPSCs) have been generated with varied efficiencies from multiple tissues. Yet, acquiring donor cells is, in most instances, an invasive procedure that requires laborious isolation. Here we present a detailed protoco
The in vitro production of mature human red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) has been the focus of research to meet the high demand for blood transfusions. However, limitations like high costs and technological requirements restrict the use of RBCs produced by iPSC...
Induced Pluriopotent Stem Cells (iPSCs) are a type of pluripotent stem cells that can be derived directly from adult somatic cells. The derived iPSCs can propagate indefinitely, as well as give rise to other cell types in the body. iPS cells, thus, hold ...
Centrosomal abnormalities in human embryonic stem cells. Z Holubcová,P Dvořák,A Hampl - 《Biometrics》 被引量: 15发表: 2007年 Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders While induced pluripotent stem cells (iPSCs) have replaced the ethically ques...