Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development | Physiological Reviews 以下为全文翻译(水平有限,仅供参考): 摘要: 体细胞核移植的发现证明,体细胞可以携带与受精卵相同的遗传密码,激活该密码的部分足以将细胞重新编程到早期发育状态。近半个世纪后,诱导多能干细胞 (iPSC...
Human induced pluripotent stem cells (iPSCs) have emerged as an invaluable resource for basic research, disease modeling, and drug discovery over recent years. Given the numerous advantages of iPSCs over alternative models—including their human origin, their ability to be differentiated into almost ...
The generation of NSCs from human induced pluripotent stem cells (hiPSCs) might overcome these difficulties, as hiPSCs could be (i) generated from easily accessible cell sources, expanded and differentiated for large-scale GMP production of transplantable cells29; (ii) manipulated to create ‘off-th...
Human iPSCs were induced to differentiate into MSCs following a clinically compliant protocol. The iPSC-MSC treatment promoted mucosal healing in colitic mice, accompanied by increased epithelial cell proliferation, CD44-positive cells, and Lgr5-positive cells. TSG-6 knockdown in iPSC-MSCs or ...
The human induced pluripotent stem cells (hiPSCs) can generate all the cells composing the human body, theoretically. Therefore, hiPSCs are thought to be a candidate source of stem cells for regenerative medicine. The major challenge of allogeneic hiPSC-derived cell products is their immunogenicity....
In the last decades, induced pluripotent stem cells (iPSCs) have extensively been used for disease modeling and drug discovery (Rowe and Daley, 2019). Moreover, iPSCs are an attractive source for regenerative medicine, as they can be generated from the patient's own cell, and the first cli...
3. The Potential of Induced Pluripotent Stem Cells in Personalized Psychiatry The best medical application of iPSCs is generally thought to be in cell transplantation therapy; however, disease modeling and drug screening could be as relevant as cell therapy, making iPSCs attractive candidates for fut...
Cellartis Human iPS Cell Line Kits contain human induced pluripotent stem (iPS) cells that are banked and characterized according to the highest industry standards, along with a starter set for the Cellartis DEF-CS Culture System. The iPS cells are adapted to the Cellartis DEF-CS Culture System...
Pluripotent cells, such as embryonic stem cells, are invaluable tools for research and can potentially serve as a source of cell- and tissue-replacement therapy. Rejection after transplantation of cells and tissue derived from embryonic stem cells is a s
Induced pluripotent stem cells (iPSCs) have become an essential research platform to study different human diseases once being discovered by Dr. Shinya Yamanaka in 2006. Another breakthrough in biomedical research is the application of CRISPR/Cas9 system for genome editing in mammalian cells. ...